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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LDLR
All Species:
12.73
Human Site:
S470
Identified Species:
31.11
UniProt:
P01130
Number Species:
9
Phosphosite Substitution
Charge Score:
0.44
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P01130
NP_000518.1
860
95376
S470
S
S
Y
D
T
V
I
S
R
D
I
Q
A
P
D
Chimpanzee
Pan troglodytes
XP_001167447
860
95392
S470
S
S
Y
D
T
V
I
S
R
D
I
Q
A
P
D
Rhesus Macaque
Macaca mulatta
NP_001028078
853
94759
S463
S
S
Y
D
T
V
I
S
R
D
L
Q
A
P
D
Dog
Lupus familis
XP_546704
1149
124413
D679
A
E
Q
E
V
L
V
D
E
Q
L
H
S
P
E
Cat
Felis silvestris
Mouse
Mus musculus
P35951
864
95116
E471
S
Y
D
T
I
I
S
E
D
L
H
A
P
D
G
Rat
Rattus norvegicus
P35952
879
96603
G471
S
Y
D
A
I
I
S
G
D
L
H
A
P
D
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510419
931
103761
E537
T
H
D
T
V
I
G
E
D
I
Q
A
P
D
G
Chicken
Gallus gallus
Q98931
917
101361
D507
A
E
Q
V
I
L
I
D
S
Q
L
N
S
P
E
Frog
Xenopus laevis
Q99087
909
101277
S468
S
H
H
E
T
V
I
S
N
Q
I
Q
A
P
D
Zebra Danio
Brachydanio rerio
NP_957217
866
95790
I460
E
R
R
E
Y
T
Q
I
V
E
Q
L
R
N
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
93.4
40.2
N.A.
77.5
75.5
N.A.
66.6
51.5
63.1
50.5
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.3
95.6
52.3
N.A.
85.5
83.7
N.A.
77.4
65.3
73.8
66.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
6.6
N.A.
6.6
6.6
N.A.
0
13.3
66.6
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
53.3
N.A.
13.3
13.3
N.A.
13.3
46.6
80
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
0
0
10
0
0
0
0
0
0
0
30
40
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
30
30
0
0
0
20
30
30
0
0
0
30
40
% D
% Glu:
10
20
0
30
0
0
0
20
10
10
0
0
0
0
20
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
10
10
0
0
0
0
0
0
30
% G
% His:
0
20
10
0
0
0
0
0
0
0
20
10
0
0
0
% H
% Ile:
0
0
0
0
30
30
50
10
0
10
30
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
20
0
0
0
20
30
10
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
10
0
0
10
0
10
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
30
60
0
% P
% Gln:
0
0
20
0
0
0
10
0
0
30
20
40
0
0
0
% Q
% Arg:
0
10
10
0
0
0
0
0
30
0
0
0
10
0
0
% R
% Ser:
60
30
0
0
0
0
20
40
10
0
0
0
20
0
0
% S
% Thr:
10
0
0
20
40
10
0
0
0
0
0
0
0
0
10
% T
% Val:
0
0
0
10
20
40
10
0
10
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
20
30
0
10
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _