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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PENK All Species: 6.06
Human Site: S183 Identified Species: 14.81
UniProt: P01210 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.33
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P01210 NP_001129162.1 267 30787 S183 S D N E E E V S K R Y G G F M
Chimpanzee Pan troglodytes XP_001155627 267 30741 S183 S D N E E E V S K R Y G G F M
Rhesus Macaque Macaca mulatta XP_001113720 253 27992 V171 E E D P K E Q V K R Y G G F L
Dog Lupus familis XP_535081 254 28765 R172 D D E D V S K R Y G G F M R A
Cat Felis silvestris
Mouse Mus musculus P22005 268 30986 M183 S T N N D E D M S K R Y G G F
Rat Rattus norvegicus P04094 269 30913 S183 S T N N D E D S T S K R Y G G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513911 267 29807 G183 G D N D E E V G K R Y G G F M
Chicken Gallus gallus XP_419213 267 30029 K183 E N D G D V S K R Y G G F M R
Frog Xenopus laevis P01212 262 29914 R179 T P G E I N K R Y G G F M R G
Zebra Danio Brachydanio rerio NP_956377 234 26115 G152 L R E I L R V G L S S E S D D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 34 72.6 N.A. 82.4 82.1 N.A. 73 71.9 60.2 44.9 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 100 46.8 80.5 N.A. 91 90.3 N.A. 85.3 84.6 73.4 60.2 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 46.6 6.6 N.A. 26.6 26.6 N.A. 80 6.6 6.6 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 73.3 13.3 N.A. 40 33.3 N.A. 86.6 33.3 13.3 6.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 40 20 20 30 0 20 0 0 0 0 0 0 10 10 % D
% Glu: 20 10 20 30 30 60 0 0 0 0 0 10 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 20 10 40 10 % F
% Gly: 10 0 10 10 0 0 0 20 0 20 30 50 50 20 20 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 10 10 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 10 0 20 10 40 10 10 0 0 0 0 % K
% Leu: 10 0 0 0 10 0 0 0 10 0 0 0 0 0 10 % L
% Met: 0 0 0 0 0 0 0 10 0 0 0 0 20 10 30 % M
% Asn: 0 10 50 20 0 10 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 10 0 10 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % Q
% Arg: 0 10 0 0 0 10 0 20 10 40 10 10 0 20 10 % R
% Ser: 40 0 0 0 0 10 10 30 10 20 10 0 10 0 0 % S
% Thr: 10 20 0 0 0 0 0 0 10 0 0 0 0 0 0 % T
% Val: 0 0 0 0 10 10 40 10 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 20 10 40 10 10 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _