Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TNF All Species: 25.76
Human Site: S157 Identified Species: 51.52
UniProt: P01375 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P01375 NP_000585.2 233 25644 S157 V L L T H T I S R I A V S Y Q
Chimpanzee Pan troglodytes Q8HZD9 232 25428 S156 V L L T H T I S R I A V S Y Q
Rhesus Macaque Macaca mulatta P48094 233 25612 S157 V L L T H T I S R I A V S Y Q
Dog Lupus familis XP_848886 233 25475 Y158 K A T P T P L Y L A H E V Q L
Cat Felis silvestris
Mouse Mus musculus P06804 235 25877 S159 V L L T H T V S R F A I S Y Q
Rat Rattus norvegicus P16599 235 25787 S159 V L L T H T V S R F A I S Y Q
Wallaby Macropus eugenll O77764 233 25678 S157 L L L T H T V S R V A L S Y Q
Platypus Ornith. anatinus XP_001515935 137 15111 T62 P D D S P I L T H N V S R F S
Chicken Gallus gallus NP_001019749 239 26297 S163 S D T S S K T S S V T A V I T
Frog Xenopus laevis NP_001108250 225 25393 L149 C K R E P L H L T H T V N V V
Zebra Danio Brachydanio rerio NP_998024 234 25786 H157 E E Q V L M S H A V M R F S E
Tiger Blowfish Takifugu rubipres NP_001033074 250 27690 Y175 L S H R V W R Y S D S I G T E
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 96.1 32.6 N.A. 79.1 78.7 70.3 34.7 25.5 31.3 29.4 28.8 N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.1 97.4 46.3 N.A. 89.7 88.5 82.4 47.2 42.6 56.2 47.8 49.2 N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 0 N.A. 80 80 73.3 0 6.6 6.6 0 0 N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 6.6 N.A. 93.3 93.3 100 26.6 20 13.3 13.3 26.6 N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 0 0 0 0 0 0 9 9 50 9 0 0 0 % A
% Cys: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 17 9 0 0 0 0 0 0 9 0 0 0 0 0 % D
% Glu: 9 9 0 9 0 0 0 0 0 0 0 9 0 0 17 % E
% Phe: 0 0 0 0 0 0 0 0 0 17 0 0 9 9 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % G
% His: 0 0 9 0 50 0 9 9 9 9 9 0 0 0 0 % H
% Ile: 0 0 0 0 0 9 25 0 0 25 0 25 0 9 0 % I
% Lys: 9 9 0 0 0 9 0 0 0 0 0 0 0 0 0 % K
% Leu: 17 50 50 0 9 9 17 9 9 0 0 9 0 0 9 % L
% Met: 0 0 0 0 0 9 0 0 0 0 9 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 9 0 0 9 0 0 % N
% Pro: 9 0 0 9 17 9 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 9 0 0 0 0 0 0 0 0 0 0 9 50 % Q
% Arg: 0 0 9 9 0 0 9 0 50 0 0 9 9 0 0 % R
% Ser: 9 9 0 17 9 0 9 59 17 0 9 9 50 9 9 % S
% Thr: 0 0 17 50 9 50 9 9 9 0 17 0 0 9 9 % T
% Val: 42 0 0 9 9 0 25 0 0 25 9 34 17 9 9 % V
% Trp: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 17 0 0 0 0 0 50 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _