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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TNF
All Species:
8.79
Human Site:
T21
Identified Species:
17.58
UniProt:
P01375
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P01375
NP_000585.2
233
25644
T21
E
E
A
L
P
K
K
T
G
G
P
Q
G
S
R
Chimpanzee
Pan troglodytes
Q8HZD9
232
25428
T21
E
E
A
L
P
K
K
T
G
G
P
Q
G
S
R
Rhesus Macaque
Macaca mulatta
P48094
233
25612
T21
E
E
A
L
P
R
K
T
A
G
P
Q
G
S
R
Dog
Lupus familis
XP_848886
233
25475
L36
P
M
T
P
P
G
R
L
Y
L
L
R
V
R
S
Cat
Felis silvestris
Mouse
Mus musculus
P06804
235
25877
M21
E
E
A
L
P
Q
K
M
G
G
F
Q
N
S
R
Rat
Rattus norvegicus
P16599
235
25787
M21
E
E
A
L
P
K
K
M
G
G
L
Q
N
S
R
Wallaby
Macropus eugenll
O77764
233
25678
A21
E
E
E
L
Q
R
K
A
R
G
P
Q
G
P
G
Platypus
Ornith. anatinus
XP_001515935
137
15111
Chicken
Gallus gallus
NP_001019749
239
26297
K24
Q
A
S
R
M
H
I
K
E
D
L
R
R
M
R
Frog
Xenopus laevis
NP_001108250
225
25393
N23
R
Q
E
R
S
N
R
N
S
T
W
R
F
V
S
Zebra Danio
Brachydanio rerio
NP_998024
234
25786
A28
V
M
V
S
R
R
K
A
G
S
S
K
S
G
V
Tiger Blowfish
Takifugu rubipres
NP_001033074
250
27690
K25
K
T
V
V
L
V
E
K
K
S
S
T
G
W
M
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
96.1
32.6
N.A.
79.1
78.7
70.3
34.7
25.5
31.3
29.4
28.8
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.1
97.4
46.3
N.A.
89.7
88.5
82.4
47.2
42.6
56.2
47.8
49.2
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
86.6
6.6
N.A.
73.3
80
53.3
0
6.6
0
13.3
6.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
20
N.A.
80
80
60
0
26.6
20
26.6
26.6
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
42
0
0
0
0
17
9
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% D
% Glu:
50
50
17
0
0
0
9
0
9
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
9
0
9
0
0
% F
% Gly:
0
0
0
0
0
9
0
0
42
50
0
0
42
9
9
% G
% His:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% I
% Lys:
9
0
0
0
0
25
59
17
9
0
0
9
0
0
0
% K
% Leu:
0
0
0
50
9
0
0
9
0
9
25
0
0
0
0
% L
% Met:
0
17
0
0
9
0
0
17
0
0
0
0
0
9
9
% M
% Asn:
0
0
0
0
0
9
0
9
0
0
0
0
17
0
0
% N
% Pro:
9
0
0
9
50
0
0
0
0
0
34
0
0
9
0
% P
% Gln:
9
9
0
0
9
9
0
0
0
0
0
50
0
0
0
% Q
% Arg:
9
0
0
17
9
25
17
0
9
0
0
25
9
9
50
% R
% Ser:
0
0
9
9
9
0
0
0
9
17
17
0
9
42
17
% S
% Thr:
0
9
9
0
0
0
0
25
0
9
0
9
0
0
0
% T
% Val:
9
0
17
9
0
9
0
0
0
0
0
0
9
9
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
9
0
0
9
0
% W
% Tyr:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _