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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HLA-DRB1 All Species: 12.73
Human Site: Y249 Identified Species: 56
UniProt: P01911 Number Species: 5
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P01911 NP_002115.2 266 29966 Y249 L G A G L F I Y F R N Q K G H
Chimpanzee Pan troglodytes P18467 273 30903 Q246 L L V G I V I Q L R A Q K G Y
Rhesus Macaque Macaca mulatta XP_001089877 266 29671 Y249 L G A G L F I Y F R N Q K G H
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P18468 264 30213 Y247 L R A G L F I Y F R N Q K G Q
Rat Rattus norvegicus P18211 264 29858 Y247 L G A G L F V Y F R N Q K G Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P23068 231 26259 L215 A L G I F F F L C S K K G Q P
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 54.2 89.4 N.A. N.A. 75.5 72.5 N.A. N.A. 44.3 N.A. N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 69.5 94.3 N.A. N.A. 86.4 83 N.A. N.A. 58.6 N.A. N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 46.6 100 N.A. N.A. 86.6 86.6 N.A. N.A. 6.6 N.A. N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 60 100 N.A. N.A. 86.6 93.3 N.A. N.A. 13.3 N.A. N.A. N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 17 0 67 0 0 0 0 0 0 0 17 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 17 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 17 84 17 0 67 0 0 0 0 0 0 % F
% Gly: 0 50 17 84 0 0 0 0 0 0 0 0 17 84 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 34 % H
% Ile: 0 0 0 17 17 0 67 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 17 17 84 0 0 % K
% Leu: 84 34 0 0 67 0 0 17 17 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 67 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 17 % P
% Gln: 0 0 0 0 0 0 0 17 0 0 0 84 0 17 34 % Q
% Arg: 0 17 0 0 0 0 0 0 0 84 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 0 0 17 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 17 0 0 17 17 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 67 0 0 0 0 0 0 17 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _