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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
APOE
All Species:
12.73
Human Site:
S281
Identified Species:
28
UniProt:
P02649
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P02649
NP_000032.1
317
36154
S281
A
F
Q
A
R
L
K
S
W
F
E
P
L
V
E
Chimpanzee
Pan troglodytes
Q9GJU3
317
36083
S281
A
F
Q
A
R
L
K
S
W
F
E
P
L
V
E
Rhesus Macaque
Macaca mulatta
Q28502
107
12364
R83
G
Q
S
T
E
E
L
R
A
R
L
A
S
H
L
Dog
Lupus familis
XP_533644
323
37206
S287
A
F
Q
A
R
L
K
S
W
F
E
P
L
L
E
Cat
Felis silvestris
Mouse
Mus musculus
P08226
311
35848
G273
I
F
Q
A
R
L
K
G
W
F
E
P
I
V
E
Rat
Rattus norvegicus
P02650
312
35735
G273
I
F
Q
A
R
I
K
G
W
F
E
P
L
V
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516358
602
66481
S572
K
I
Q
E
Q
L
R
S
W
F
Q
P
L
V
Q
Chicken
Gallus gallus
P08250
264
30662
E236
K
M
T
P
L
V
Q
E
F
R
E
R
L
T
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
O42364
281
31655
Q257
S
L
L
A
P
Y
S
Q
K
I
R
E
Q
L
Q
Tiger Blowfish
Takifugu rubipres
NP_001072103
276
31224
E247
S
L
E
G
K
M
D
E
L
K
D
L
L
S
P
Fruit Fly
Dros. melanogaster
NP_996484
326
39804
D275
E
R
R
D
P
L
R
D
R
L
D
P
L
R
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.1
31.5
68.1
N.A.
71.2
70.3
N.A.
26.4
20.1
N.A.
28.3
25.5
22.7
N.A.
N.A.
N.A.
Protein Similarity:
100
97.7
31.8
80.8
N.A.
83.2
82.6
N.A.
39
42.5
N.A.
52.3
50.4
42
N.A.
N.A.
N.A.
P-Site Identity:
100
100
0
93.3
N.A.
80
80
N.A.
53.3
13.3
N.A.
6.6
6.6
26.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
0
100
N.A.
86.6
86.6
N.A.
80
33.3
N.A.
26.6
40
46.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
28
0
0
55
0
0
0
0
10
0
0
10
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
10
0
0
10
10
0
0
19
0
0
0
0
% D
% Glu:
10
0
10
10
10
10
0
19
0
0
55
10
0
0
55
% E
% Phe:
0
46
0
0
0
0
0
0
10
55
0
0
0
0
0
% F
% Gly:
10
0
0
10
0
0
0
19
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% H
% Ile:
19
10
0
0
0
10
0
0
0
10
0
0
10
0
0
% I
% Lys:
19
0
0
0
10
0
46
0
10
10
0
0
0
0
0
% K
% Leu:
0
19
10
0
10
55
10
0
10
10
10
10
73
19
10
% L
% Met:
0
10
0
0
0
10
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
10
19
0
0
0
0
0
0
64
0
0
19
% P
% Gln:
0
10
55
0
10
0
10
10
0
0
10
0
10
0
19
% Q
% Arg:
0
10
10
0
46
0
19
10
10
19
10
10
0
10
0
% R
% Ser:
19
0
10
0
0
0
10
37
0
0
0
0
10
10
0
% S
% Thr:
0
0
10
10
0
0
0
0
0
0
0
0
0
10
0
% T
% Val:
0
0
0
0
0
10
0
0
0
0
0
0
0
46
0
% V
% Trp:
0
0
0
0
0
0
0
0
55
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _