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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TTR
All Species:
40.3
Human Site:
S137
Identified Species:
80.61
UniProt:
P02766
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P02766
NP_000362.1
147
15887
S137
L
L
S
P
Y
S
Y
S
T
T
A
V
V
T
N
Chimpanzee
Pan troglodytes
Q5U7I5
147
15854
S137
L
L
S
P
Y
S
Y
S
T
T
A
V
V
T
I
Rhesus Macaque
Macaca mulatta
XP_001099005
147
15812
S137
L
L
S
P
Y
S
Y
S
T
T
A
V
V
T
N
Dog
Lupus familis
XP_537290
147
15850
S137
L
L
S
P
Y
S
Y
S
T
T
A
L
V
S
N
Cat
Felis silvestris
Mouse
Mus musculus
P07309
147
15757
S137
L
L
S
P
Y
S
Y
S
T
T
A
V
V
S
N
Rat
Rattus norvegicus
P02767
147
15701
S137
L
L
S
P
Y
S
Y
S
T
T
A
V
V
S
N
Wallaby
Macropus eugenll
P42204
149
16427
S139
L
L
S
P
Y
S
F
S
T
T
A
I
V
S
N
Platypus
Ornith. anatinus
XP_001515893
149
16330
S139
L
I
S
P
F
S
F
S
T
T
A
V
V
S
N
Chicken
Gallus gallus
P27731
150
16291
S140
L
L
S
P
F
S
Y
S
T
T
A
V
V
S
D
Frog
Xenopus laevis
B7ZS96
153
16673
S141
L
L
T
P
Y
S
F
S
S
T
A
I
V
S
E
Zebra Danio
Brachydanio rerio
Q06S87
138
15467
R129
H
V
P
L
L
L
S
R
F
S
Y
S
T
Y
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793771
147
16122
L136
H
Y
H
V
P
L
L
L
S
P
F
S
Y
S
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
93.8
85
N.A.
81.6
82.3
70.4
65.7
73.3
55.5
29.2
N.A.
N.A.
N.A.
N.A.
38.1
Protein Similarity:
100
99.3
97.2
91.8
N.A.
91.8
91.8
83.2
83.8
86.6
72.5
48.2
N.A.
N.A.
N.A.
N.A.
51
P-Site Identity:
100
93.3
100
86.6
N.A.
93.3
93.3
80
73.3
80
60
0
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
93.3
100
100
N.A.
100
100
100
100
100
93.3
13.3
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
84
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% E
% Phe:
0
0
0
0
17
0
25
0
9
0
9
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
17
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
9
0
0
0
0
0
0
0
0
0
17
0
0
9
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
84
75
0
9
9
17
9
9
0
0
0
9
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
59
% N
% Pro:
0
0
9
84
9
0
0
0
0
9
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
9
% R
% Ser:
0
0
75
0
0
84
9
84
17
9
0
17
0
67
0
% S
% Thr:
0
0
9
0
0
0
0
0
75
84
0
0
9
25
9
% T
% Val:
0
9
0
9
0
0
0
0
0
0
0
59
84
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
9
0
0
67
0
59
0
0
0
9
0
9
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _