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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TTR
All Species:
31.82
Human Site:
S66
Identified Species:
63.64
UniProt:
P02766
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P02766
NP_000362.1
147
15887
S66
D
T
W
E
P
F
A
S
G
K
T
S
E
S
G
Chimpanzee
Pan troglodytes
Q5U7I5
147
15854
S66
E
T
W
E
P
F
A
S
G
K
T
S
E
S
G
Rhesus Macaque
Macaca mulatta
XP_001099005
147
15812
S66
E
T
W
A
P
F
A
S
G
K
T
S
E
S
G
Dog
Lupus familis
XP_537290
147
15850
S66
E
T
W
E
P
F
A
S
G
K
T
S
E
F
G
Cat
Felis silvestris
Mouse
Mus musculus
P07309
147
15757
S66
G
S
W
E
P
F
A
S
G
K
T
A
E
S
G
Rat
Rattus norvegicus
P02767
147
15701
S66
G
S
W
E
P
F
A
S
G
K
T
A
E
S
G
Wallaby
Macropus eugenll
P42204
149
16427
A68
Q
T
W
E
L
F
A
A
G
K
T
N
D
N
G
Platypus
Ornith. anatinus
XP_001515893
149
16330
T68
E
S
W
E
L
F
A
T
G
K
T
T
E
F
G
Chicken
Gallus gallus
P27731
150
16291
T69
G
T
W
Q
D
F
A
T
G
K
T
T
E
F
G
Frog
Xenopus laevis
B7ZS96
153
16673
S70
G
K
W
E
Q
I
T
S
G
K
T
T
E
L
G
Zebra Danio
Brachydanio rerio
Q06S87
138
15467
W58
L
D
P
V
S
S
A
W
N
I
L
T
T
G
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793771
147
16122
G65
E
V
Y
H
L
M
A
G
Q
W
K
K
I
S
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
93.8
85
N.A.
81.6
82.3
70.4
65.7
73.3
55.5
29.2
N.A.
N.A.
N.A.
N.A.
38.1
Protein Similarity:
100
99.3
97.2
91.8
N.A.
91.8
91.8
83.2
83.8
86.6
72.5
48.2
N.A.
N.A.
N.A.
N.A.
51
P-Site Identity:
100
93.3
86.6
86.6
N.A.
80
80
60
60
60
53.3
6.6
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
100
93.3
93.3
N.A.
93.3
93.3
86.6
86.6
80
60
13.3
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
0
0
92
9
0
0
0
17
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
9
0
0
9
0
0
0
0
0
0
0
9
0
0
% D
% Glu:
42
0
0
67
0
0
0
0
0
0
0
0
75
0
9
% E
% Phe:
0
0
0
0
0
75
0
0
0
0
0
0
0
25
0
% F
% Gly:
34
0
0
0
0
0
0
9
84
0
0
0
0
9
84
% G
% His:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
9
0
0
0
9
0
0
9
0
9
% I
% Lys:
0
9
0
0
0
0
0
0
0
84
9
9
0
0
0
% K
% Leu:
9
0
0
0
25
0
0
0
0
0
9
0
0
9
0
% L
% Met:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
9
0
0
9
0
9
0
% N
% Pro:
0
0
9
0
50
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
9
0
0
9
9
0
0
0
9
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
25
0
0
9
9
0
59
0
0
0
34
0
50
0
% S
% Thr:
0
50
0
0
0
0
9
17
0
0
84
34
9
0
0
% T
% Val:
0
9
0
9
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
84
0
0
0
0
9
0
9
0
0
0
0
0
% W
% Tyr:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _