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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TTR
All Species:
12.73
Human Site:
T25
Identified Species:
25.45
UniProt:
P02766
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P02766
NP_000362.1
147
15887
T25
S
E
A
G
P
T
G
T
G
E
S
K
C
P
L
Chimpanzee
Pan troglodytes
Q5U7I5
147
15854
T25
S
E
A
G
P
T
G
T
G
E
S
K
C
P
L
Rhesus Macaque
Macaca mulatta
XP_001099005
147
15812
V25
S
E
A
G
P
T
G
V
D
E
S
K
C
P
L
Dog
Lupus familis
XP_537290
147
15850
T25
S
E
A
S
P
A
G
T
S
G
P
K
C
P
L
Cat
Felis silvestris
Mouse
Mus musculus
P07309
147
15757
A25
S
E
A
G
P
A
G
A
G
E
S
K
C
P
L
Rat
Rattus norvegicus
P02767
147
15701
A25
S
E
A
G
P
G
G
A
G
E
S
K
C
P
L
Wallaby
Macropus eugenll
P42204
149
16427
G27
T
A
A
V
H
H
E
G
E
H
S
K
C
P
L
Platypus
Ornith. anatinus
XP_001515893
149
16330
S27
A
T
P
V
V
H
S
S
V
D
S
K
C
P
L
Chicken
Gallus gallus
P27731
150
16291
S28
A
P
L
V
S
H
G
S
V
D
S
K
C
P
L
Frog
Xenopus laevis
B7ZS96
153
16673
E29
P
G
H
A
S
H
G
E
A
D
S
K
C
P
L
Zebra Danio
Brachydanio rerio
Q06S87
138
15467
N19
V
S
A
D
K
H
I
N
M
S
A
T
L
L
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793771
147
16122
L25
A
D
E
G
N
V
A
L
T
T
V
E
T
A
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
93.8
85
N.A.
81.6
82.3
70.4
65.7
73.3
55.5
29.2
N.A.
N.A.
N.A.
N.A.
38.1
Protein Similarity:
100
99.3
97.2
91.8
N.A.
91.8
91.8
83.2
83.8
86.6
72.5
48.2
N.A.
N.A.
N.A.
N.A.
51
P-Site Identity:
100
100
86.6
66.6
N.A.
86.6
86.6
40
33.3
40
40
6.6
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
86.6
66.6
N.A.
86.6
86.6
46.6
53.3
60
46.6
13.3
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
25
9
67
9
0
17
9
17
9
0
9
0
0
9
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
84
0
0
% C
% Asp:
0
9
0
9
0
0
0
0
9
25
0
0
0
0
0
% D
% Glu:
0
50
9
0
0
0
9
9
9
42
0
9
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
9
0
50
0
9
67
9
34
9
0
0
0
0
9
% G
% His:
0
0
9
0
9
42
0
0
0
9
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
9
0
0
0
0
0
0
84
0
0
0
% K
% Leu:
0
0
9
0
0
0
0
9
0
0
0
0
9
9
84
% L
% Met:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
9
0
0
9
0
0
0
0
0
0
0
% N
% Pro:
9
9
9
0
50
0
0
0
0
0
9
0
0
84
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
50
9
0
9
17
0
9
17
9
9
75
0
0
0
9
% S
% Thr:
9
9
0
0
0
25
0
25
9
9
0
9
9
0
0
% T
% Val:
9
0
0
25
9
9
0
9
17
0
9
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _