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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ESR1
All Species:
18.48
Human Site:
S305
Identified Species:
50.83
UniProt:
P03372
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P03372
NP_000116.2
595
66216
S305
I
K
R
S
K
K
N
S
L
A
L
S
L
T
A
Chimpanzee
Pan troglodytes
XP_001170268
530
59089
A275
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
Rhesus Macaque
Macaca mulatta
Q9TTE5
279
31087
L33
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
Dog
Lupus familis
XP_533454
596
66219
S306
I
K
H
T
K
K
N
S
P
A
L
S
L
T
A
Cat
Felis silvestris
Mouse
Mus musculus
P19785
599
66936
S309
I
K
H
T
K
K
N
S
P
A
L
S
L
T
A
Rat
Rattus norvegicus
P06211
600
67011
S310
I
K
H
T
K
K
N
S
P
A
L
S
L
T
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P06212
589
66728
S299
V
K
H
N
K
K
N
S
P
A
L
S
L
T
A
Frog
Xenopus laevis
P81559
586
66062
S297
S
V
K
S
M
K
L
S
P
V
L
S
L
T
A
Zebra Danio
Brachydanio rerio
P57717
569
62828
V273
K
K
R
S
G
G
V
V
S
T
L
C
M
S
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
44.3
29
90
N.A.
88.9
88.1
N.A.
N.A.
78.1
69.9
48.4
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
64
38.8
94.8
N.A.
93.4
92.8
N.A.
N.A.
86.8
81.6
63
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
0
6.6
80
N.A.
80
80
N.A.
N.A.
73.3
53.3
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
26.6
20
86.6
N.A.
86.6
86.6
N.A.
N.A.
86.6
60
40
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
12
0
56
0
0
12
0
67
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
12
0
0
12
0
12
0
0
12
0
12
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
12
12
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
45
0
0
0
0
0
0
0
0
12
0
0
0
% H
% Ile:
45
0
0
0
0
0
0
0
0
0
0
0
0
0
12
% I
% Lys:
12
67
12
0
56
67
0
0
0
0
0
0
0
0
0
% K
% Leu:
23
0
12
0
12
23
12
12
12
12
89
0
67
12
0
% L
% Met:
0
0
0
0
12
0
0
0
0
0
0
0
12
0
0
% M
% Asn:
0
0
0
12
0
0
56
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
12
0
0
0
0
0
56
12
12
0
0
0
23
% P
% Gln:
0
0
0
0
12
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
23
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
12
12
0
34
0
0
0
67
12
0
0
67
0
12
0
% S
% Thr:
0
0
0
45
0
0
0
0
12
12
0
0
0
67
0
% T
% Val:
12
23
0
0
0
0
23
12
0
12
0
0
12
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _