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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCR
All Species:
25.15
Human Site:
S298
Identified Species:
39.52
UniProt:
P04035
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P04035
NP_000850.1
888
97476
S298
L
G
L
D
E
N
V
S
K
R
I
E
P
S
V
Chimpanzee
Pan troglodytes
XP_001148324
888
97313
S298
L
G
L
D
E
N
V
S
K
R
I
E
P
S
V
Rhesus Macaque
Macaca mulatta
XP_001104607
888
97210
S298
L
G
L
D
E
N
V
S
K
R
I
E
P
S
V
Dog
Lupus familis
XP_536323
888
97475
S298
L
G
L
D
E
N
V
S
K
R
I
E
P
S
V
Cat
Felis silvestris
Mouse
Mus musculus
Q01237
887
97003
S298
L
G
L
D
E
D
V
S
K
R
I
E
P
S
V
Rat
Rattus norvegicus
P51639
887
96670
S298
L
G
L
A
E
D
V
S
K
R
I
E
P
S
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_989816
875
95421
S296
K
R
I
E
P
N
V
S
L
W
Q
F
Y
L
S
Frog
Xenopus laevis
P20715
883
96702
P300
T
M
L
D
D
M
M
P
K
R
V
E
P
S
M
Zebra Danio
Brachydanio rerio
NP_001119931
893
97691
P299
M
S
L
N
E
N
L
P
K
R
I
E
P
D
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P14773
920
98299
N346
L
S
L
N
V
S
N
N
R
T
E
S
G
E
I
Honey Bee
Apis mellifera
XP_623118
908
99432
Y301
S
H
V
I
V
N
S
Y
N
E
T
E
D
S
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
P16393
932
100947
D297
Y
D
G
N
L
L
T
D
K
K
I
D
P
T
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O24594
579
60912
A54
A
L
F
A
A
S
L
A
Y
L
M
R
R
W
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P14891
592
63579
F67
A
V
F
F
T
L
F
F
S
V
A
Y
Y
L
L
Baker's Yeast
Sacchar. cerevisiae
P12683
1054
115607
V443
L
Y
F
D
K
E
R
V
S
L
P
D
F
I
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.7
95.7
N.A.
93.3
92.7
N.A.
N.A.
85.1
80.9
77.8
N.A.
47.2
51.2
N.A.
56.3
Protein Similarity:
100
99.7
99.3
97.3
N.A.
96
95.8
N.A.
N.A.
91.6
89.5
86.7
N.A.
64.6
69.2
N.A.
70.6
P-Site Identity:
100
100
100
100
N.A.
93.3
86.6
N.A.
N.A.
20
46.6
53.3
N.A.
13.3
20
N.A.
20
P-Site Similarity:
100
100
100
100
N.A.
100
93.3
N.A.
N.A.
33.3
73.3
80
N.A.
46.6
26.6
N.A.
53.3
Percent
Protein Identity:
N.A.
33.5
N.A.
34.5
35.1
N.A.
Protein Similarity:
N.A.
46.8
N.A.
47.5
51
N.A.
P-Site Identity:
N.A.
0
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
6.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
0
0
14
7
0
0
7
0
0
7
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
0
47
7
14
0
7
0
0
0
14
7
7
0
% D
% Glu:
0
0
0
7
47
7
0
0
0
7
7
60
0
7
0
% E
% Phe:
0
0
20
7
0
0
7
7
0
0
0
7
7
0
0
% F
% Gly:
0
40
7
0
0
0
0
0
0
0
0
0
7
0
0
% G
% His:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
7
7
0
0
0
0
0
0
54
0
0
7
7
% I
% Lys:
7
0
0
0
7
0
0
0
60
7
0
0
0
0
0
% K
% Leu:
54
7
60
0
7
14
14
0
7
14
0
0
0
14
7
% L
% Met:
7
7
0
0
0
7
7
0
0
0
7
0
0
0
20
% M
% Asn:
0
0
0
20
0
47
7
7
7
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
7
0
0
14
0
0
7
0
60
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% Q
% Arg:
0
7
0
0
0
0
7
0
7
54
0
7
7
0
7
% R
% Ser:
7
14
0
0
0
14
7
47
14
0
0
7
0
54
14
% S
% Thr:
7
0
0
0
7
0
7
0
0
7
7
0
0
7
7
% T
% Val:
0
7
7
0
14
0
47
7
0
7
7
0
0
0
40
% V
% Trp:
0
0
0
0
0
0
0
0
0
7
0
0
0
7
0
% W
% Tyr:
7
7
0
0
0
0
0
7
7
0
0
7
14
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _