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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCR
All Species:
43.03
Human Site:
S463
Identified Species:
67.62
UniProt:
P04035
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P04035
NP_000850.1
888
97476
S463
E
K
G
A
K
F
L
S
D
A
E
I
I
Q
L
Chimpanzee
Pan troglodytes
XP_001148324
888
97313
S463
E
K
G
A
K
F
L
S
D
A
E
I
I
Q
L
Rhesus Macaque
Macaca mulatta
XP_001104607
888
97210
S463
E
K
G
A
K
F
L
S
D
A
E
I
I
Q
L
Dog
Lupus familis
XP_536323
888
97475
S463
E
K
G
A
K
F
L
S
D
A
E
I
I
Q
L
Cat
Felis silvestris
Mouse
Mus musculus
Q01237
887
97003
S462
E
K
G
A
K
F
L
S
D
A
E
I
I
Q
L
Rat
Rattus norvegicus
P51639
887
96670
S462
E
K
G
A
K
F
L
S
D
A
E
I
I
Q
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_989816
875
95421
T450
E
K
G
A
K
F
L
T
D
A
E
V
I
S
L
Frog
Xenopus laevis
P20715
883
96702
T458
D
K
G
A
Q
Y
L
T
D
A
E
V
I
S
L
Zebra Danio
Brachydanio rerio
NP_001119931
893
97691
S468
D
M
G
A
R
Y
L
S
D
E
E
V
I
V
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P14773
920
98299
S487
G
S
G
P
A
A
L
S
D
E
E
I
V
S
I
Honey Bee
Apis mellifera
XP_623118
908
99432
T461
E
L
G
A
N
G
L
T
D
E
E
V
I
Q
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
P16393
932
100947
T479
G
K
G
P
N
A
L
T
D
D
E
V
Q
L
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O24594
579
60912
R190
G
I
R
R
E
A
L
R
R
I
T
G
R
D
I
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P14891
592
63579
R203
C
K
R
A
A
S
I
R
R
E
A
L
Q
R
V
Baker's Yeast
Sacchar. cerevisiae
P12683
1054
115607
K617
S
G
N
T
K
Q
L
K
N
K
E
V
A
A
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.7
95.7
N.A.
93.3
92.7
N.A.
N.A.
85.1
80.9
77.8
N.A.
47.2
51.2
N.A.
56.3
Protein Similarity:
100
99.7
99.3
97.3
N.A.
96
95.8
N.A.
N.A.
91.6
89.5
86.7
N.A.
64.6
69.2
N.A.
70.6
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
80
60
53.3
N.A.
40
60
N.A.
40
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
93.3
93.3
80
N.A.
53.3
73.3
N.A.
53.3
Percent
Protein Identity:
N.A.
33.5
N.A.
34.5
35.1
N.A.
Protein Similarity:
N.A.
46.8
N.A.
47.5
51
N.A.
P-Site Identity:
N.A.
6.6
N.A.
13.3
26.6
N.A.
P-Site Similarity:
N.A.
20
N.A.
40
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
74
14
20
0
0
0
54
7
0
7
7
0
% A
% Cys:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
14
0
0
0
0
0
0
0
80
7
0
0
0
7
0
% D
% Glu:
54
0
0
0
7
0
0
0
0
27
87
0
0
0
0
% E
% Phe:
0
0
0
0
0
47
0
0
0
0
0
0
0
0
0
% F
% Gly:
20
7
80
0
0
7
0
0
0
0
0
7
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
0
0
0
7
0
0
7
0
47
67
0
14
% I
% Lys:
0
67
0
0
54
0
0
7
0
7
0
0
0
0
0
% K
% Leu:
0
7
0
0
0
0
94
0
0
0
0
7
0
7
80
% L
% Met:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
7
0
14
0
0
0
7
0
0
0
0
0
0
% N
% Pro:
0
0
0
14
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
7
7
0
0
0
0
0
0
14
47
0
% Q
% Arg:
0
0
14
7
7
0
0
14
14
0
0
0
7
7
0
% R
% Ser:
7
7
0
0
0
7
0
54
0
0
0
0
0
20
0
% S
% Thr:
0
0
0
7
0
0
0
27
0
0
7
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
40
7
7
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
14
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _