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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCR
All Species:
38.48
Human Site:
S500
Identified Species:
60.48
UniProt:
P04035
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P04035
NP_000850.1
888
97476
S500
S
I
R
R
Q
L
L
S
K
K
L
S
E
P
S
Chimpanzee
Pan troglodytes
XP_001148324
888
97313
S500
S
I
R
R
Q
L
L
S
K
K
L
S
E
P
S
Rhesus Macaque
Macaca mulatta
XP_001104607
888
97210
S500
S
I
R
R
Q
L
L
S
K
K
L
S
E
P
S
Dog
Lupus familis
XP_536323
888
97475
S500
S
I
R
R
Q
L
L
S
R
K
L
P
E
P
S
Cat
Felis silvestris
Mouse
Mus musculus
Q01237
887
97003
S499
S
I
R
R
Q
L
L
S
T
K
L
A
E
P
S
Rat
Rattus norvegicus
P51639
887
96670
S499
S
I
R
R
Q
L
L
S
A
K
L
A
E
P
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_989816
875
95421
S487
S
I
R
R
Q
M
L
S
Q
K
L
P
E
P
S
Frog
Xenopus laevis
P20715
883
96702
S495
A
I
R
R
Q
M
L
S
D
K
L
P
Q
R
S
Zebra Danio
Brachydanio rerio
NP_001119931
893
97691
S505
M
I
R
R
K
M
L
S
P
K
F
P
E
P
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P14773
920
98299
S527
I
R
R
Q
I
I
G
S
R
A
K
M
P
V
G
Honey Bee
Apis mellifera
XP_623118
908
99432
G498
E
I
R
R
F
I
I
G
E
A
G
N
F
L
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
P16393
932
100947
S516
A
V
R
R
Q
I
I
S
K
L
L
P
I
T
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O24594
579
60912
V226
V
G
Y
V
Q
L
P
V
G
V
A
G
P
L
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P14891
592
63579
Y239
C
C
E
M
P
V
G
Y
I
Q
I
P
V
G
I
Baker's Yeast
Sacchar. cerevisiae
P12683
1054
115607
I655
V
R
R
K
A
L
S
I
L
A
E
A
P
V
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.7
95.7
N.A.
93.3
92.7
N.A.
N.A.
85.1
80.9
77.8
N.A.
47.2
51.2
N.A.
56.3
Protein Similarity:
100
99.7
99.3
97.3
N.A.
96
95.8
N.A.
N.A.
91.6
89.5
86.7
N.A.
64.6
69.2
N.A.
70.6
P-Site Identity:
100
100
100
86.6
N.A.
86.6
86.6
N.A.
N.A.
80
60
60
N.A.
13.3
20
N.A.
40
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
N.A.
93.3
80
73.3
N.A.
33.3
46.6
N.A.
66.6
Percent
Protein Identity:
N.A.
33.5
N.A.
34.5
35.1
N.A.
Protein Similarity:
N.A.
46.8
N.A.
47.5
51
N.A.
P-Site Identity:
N.A.
13.3
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
20
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
0
0
0
7
0
0
0
7
20
7
20
0
0
0
% A
% Cys:
7
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
14
% D
% Glu:
7
0
7
0
0
0
0
0
7
0
7
0
54
0
0
% E
% Phe:
0
0
0
0
7
0
0
0
0
0
7
0
7
0
0
% F
% Gly:
0
7
0
0
0
0
14
7
7
0
7
7
0
7
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
67
0
0
7
20
14
7
7
0
7
0
7
0
7
% I
% Lys:
0
0
0
7
7
0
0
0
27
60
7
0
0
0
0
% K
% Leu:
0
0
0
0
0
54
60
0
7
7
60
0
0
14
14
% L
% Met:
7
0
0
7
0
20
0
0
0
0
0
7
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% N
% Pro:
0
0
0
0
7
0
7
0
7
0
0
40
20
54
0
% P
% Gln:
0
0
0
7
67
0
0
0
7
7
0
0
7
0
0
% Q
% Arg:
0
14
87
74
0
0
0
0
14
0
0
0
0
7
0
% R
% Ser:
47
0
0
0
0
0
7
74
0
0
0
20
0
0
60
% S
% Thr:
0
0
0
0
0
0
0
0
7
0
0
0
0
7
0
% T
% Val:
14
7
0
7
0
7
0
7
0
7
0
0
7
14
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
0
0
7
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _