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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGCR All Species: 25.15
Human Site: S602 Identified Species: 39.52
UniProt: P04035 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P04035 NP_000850.1 888 97476 S602 R L P R A C D S A E V K A W L
Chimpanzee Pan troglodytes XP_001148324 888 97313 S602 R L P R A C D S A E V K A W L
Rhesus Macaque Macaca mulatta XP_001104607 888 97210 S602 R L P R A C D S A E V K A W L
Dog Lupus familis XP_536323 888 97475 S602 R L P R A C D S A E V K A W L
Cat Felis silvestris
Mouse Mus musculus Q01237 887 97003 S601 R L P R A C D S A E V K T W L
Rat Rattus norvegicus P51639 887 96670 S601 R L P R A C D S A E V K S W L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_989816 875 95421 A589 R L P S A C Q A A E V K A W L
Frog Xenopus laevis P20715 883 96702 A597 R L P T A C D A A E V K A W L
Zebra Danio Brachydanio rerio NP_001119931 893 97691 A607 R F P S A C Q A A E V K A W L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P14773 920 98299 A628 R F P S V A R A A E A K S W I
Honey Bee Apis mellifera XP_623118 908 99432 A599 R F P N I V R A S E A M A W M
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus P16393 932 100947 A618 R L P S A Q E A G A I K Q W L
Poplar Tree Populus trichocarpa
Maize Zea mays O24594 579 60912 L319 R S S R F A R L Q G V Q C A M
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P14891 592 63579 S332 A V V F N R S S R F A R L Q S
Baker's Yeast Sacchar. cerevisiae P12683 1054 115607 S757 R F P T L K R S G A C K I W L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 98.7 95.7 N.A. 93.3 92.7 N.A. N.A. 85.1 80.9 77.8 N.A. 47.2 51.2 N.A. 56.3
Protein Similarity: 100 99.7 99.3 97.3 N.A. 96 95.8 N.A. N.A. 91.6 89.5 86.7 N.A. 64.6 69.2 N.A. 70.6
P-Site Identity: 100 100 100 100 N.A. 93.3 93.3 N.A. N.A. 80 86.6 73.3 N.A. 40 33.3 N.A. 46.6
P-Site Similarity: 100 100 100 100 N.A. 93.3 100 N.A. N.A. 86.6 93.3 80 N.A. 60 53.3 N.A. 66.6
Percent
Protein Identity: N.A. 33.5 N.A. 34.5 35.1 N.A.
Protein Similarity: N.A. 46.8 N.A. 47.5 51 N.A.
P-Site Identity: N.A. 20 N.A. 6.6 40 N.A.
P-Site Similarity: N.A. 33.3 N.A. 20 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 67 14 0 40 67 14 20 0 54 7 0 % A
% Cys: 0 0 0 0 0 60 0 0 0 0 7 0 7 0 0 % C
% Asp: 0 0 0 0 0 0 47 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 7 0 0 74 0 0 0 0 0 % E
% Phe: 0 27 0 7 7 0 0 0 0 7 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 14 7 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 7 0 0 0 0 0 7 0 7 0 7 % I
% Lys: 0 0 0 0 0 7 0 0 0 0 0 80 0 0 0 % K
% Leu: 0 60 0 0 7 0 0 7 0 0 0 0 7 0 74 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 14 % M
% Asn: 0 0 0 7 7 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 87 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 7 14 0 7 0 0 7 7 7 0 % Q
% Arg: 94 0 0 47 0 7 27 0 7 0 0 7 0 0 0 % R
% Ser: 0 7 7 27 0 0 7 54 7 0 0 0 14 0 7 % S
% Thr: 0 0 0 14 0 0 0 0 0 0 0 0 7 0 0 % T
% Val: 0 7 7 0 7 7 0 0 0 0 67 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 87 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _