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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCR
All Species:
25.15
Human Site:
S602
Identified Species:
39.52
UniProt:
P04035
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P04035
NP_000850.1
888
97476
S602
R
L
P
R
A
C
D
S
A
E
V
K
A
W
L
Chimpanzee
Pan troglodytes
XP_001148324
888
97313
S602
R
L
P
R
A
C
D
S
A
E
V
K
A
W
L
Rhesus Macaque
Macaca mulatta
XP_001104607
888
97210
S602
R
L
P
R
A
C
D
S
A
E
V
K
A
W
L
Dog
Lupus familis
XP_536323
888
97475
S602
R
L
P
R
A
C
D
S
A
E
V
K
A
W
L
Cat
Felis silvestris
Mouse
Mus musculus
Q01237
887
97003
S601
R
L
P
R
A
C
D
S
A
E
V
K
T
W
L
Rat
Rattus norvegicus
P51639
887
96670
S601
R
L
P
R
A
C
D
S
A
E
V
K
S
W
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_989816
875
95421
A589
R
L
P
S
A
C
Q
A
A
E
V
K
A
W
L
Frog
Xenopus laevis
P20715
883
96702
A597
R
L
P
T
A
C
D
A
A
E
V
K
A
W
L
Zebra Danio
Brachydanio rerio
NP_001119931
893
97691
A607
R
F
P
S
A
C
Q
A
A
E
V
K
A
W
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P14773
920
98299
A628
R
F
P
S
V
A
R
A
A
E
A
K
S
W
I
Honey Bee
Apis mellifera
XP_623118
908
99432
A599
R
F
P
N
I
V
R
A
S
E
A
M
A
W
M
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
P16393
932
100947
A618
R
L
P
S
A
Q
E
A
G
A
I
K
Q
W
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O24594
579
60912
L319
R
S
S
R
F
A
R
L
Q
G
V
Q
C
A
M
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P14891
592
63579
S332
A
V
V
F
N
R
S
S
R
F
A
R
L
Q
S
Baker's Yeast
Sacchar. cerevisiae
P12683
1054
115607
S757
R
F
P
T
L
K
R
S
G
A
C
K
I
W
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.7
95.7
N.A.
93.3
92.7
N.A.
N.A.
85.1
80.9
77.8
N.A.
47.2
51.2
N.A.
56.3
Protein Similarity:
100
99.7
99.3
97.3
N.A.
96
95.8
N.A.
N.A.
91.6
89.5
86.7
N.A.
64.6
69.2
N.A.
70.6
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
N.A.
80
86.6
73.3
N.A.
40
33.3
N.A.
46.6
P-Site Similarity:
100
100
100
100
N.A.
93.3
100
N.A.
N.A.
86.6
93.3
80
N.A.
60
53.3
N.A.
66.6
Percent
Protein Identity:
N.A.
33.5
N.A.
34.5
35.1
N.A.
Protein Similarity:
N.A.
46.8
N.A.
47.5
51
N.A.
P-Site Identity:
N.A.
20
N.A.
6.6
40
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
20
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
67
14
0
40
67
14
20
0
54
7
0
% A
% Cys:
0
0
0
0
0
60
0
0
0
0
7
0
7
0
0
% C
% Asp:
0
0
0
0
0
0
47
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
7
0
0
74
0
0
0
0
0
% E
% Phe:
0
27
0
7
7
0
0
0
0
7
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
14
7
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
7
0
0
0
0
0
7
0
7
0
7
% I
% Lys:
0
0
0
0
0
7
0
0
0
0
0
80
0
0
0
% K
% Leu:
0
60
0
0
7
0
0
7
0
0
0
0
7
0
74
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
14
% M
% Asn:
0
0
0
7
7
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
87
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
7
14
0
7
0
0
7
7
7
0
% Q
% Arg:
94
0
0
47
0
7
27
0
7
0
0
7
0
0
0
% R
% Ser:
0
7
7
27
0
0
7
54
7
0
0
0
14
0
7
% S
% Thr:
0
0
0
14
0
0
0
0
0
0
0
0
7
0
0
% T
% Val:
0
7
7
0
7
7
0
0
0
0
67
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
87
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _