KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCR
All Species:
12.12
Human Site:
T286
Identified Species:
19.05
UniProt:
P04035
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P04035
NP_000850.1
888
97476
T286
P
Q
N
S
T
A
D
T
S
K
V
S
L
G
L
Chimpanzee
Pan troglodytes
XP_001148324
888
97313
T286
P
Q
N
S
T
A
D
T
S
K
V
S
L
G
L
Rhesus Macaque
Macaca mulatta
XP_001104607
888
97210
T286
P
Q
N
S
T
A
D
T
S
K
V
S
L
G
L
Dog
Lupus familis
XP_536323
888
97475
N286
P
Q
N
S
T
S
E
N
S
R
V
S
L
G
L
Cat
Felis silvestris
Mouse
Mus musculus
Q01237
887
97003
Q286
P
Q
N
S
T
A
E
Q
A
K
V
S
L
G
L
Rat
Rattus norvegicus
P51639
887
96670
Q286
P
Q
N
S
T
A
E
Q
S
K
V
S
L
G
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_989816
875
95421
D284
V
E
N
A
V
G
L
D
E
N
A
P
K
R
I
Frog
Xenopus laevis
P20715
883
96702
D288
Q
N
S
T
S
I
S
D
H
E
V
T
T
M
L
Zebra Danio
Brachydanio rerio
NP_001119931
893
97691
L287
S
S
D
G
T
L
D
L
P
E
V
G
M
S
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P14773
920
98299
T334
D
Y
D
A
V
D
K
T
L
T
P
T
L
S
L
Honey Bee
Apis mellifera
XP_623118
908
99432
V289
E
D
T
V
E
G
K
V
S
S
T
N
S
H
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
P16393
932
100947
S285
S
N
D
T
E
L
M
S
R
D
M
L
Y
D
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O24594
579
60912
N42
P
L
P
I
R
H
T
N
L
I
F
S
A
L
F
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P14891
592
63579
L55
S
D
A
L
P
L
P
L
Y
L
T
N
A
V
F
Baker's Yeast
Sacchar. cerevisiae
P12683
1054
115607
D431
F
G
A
N
W
V
N
D
A
F
N
S
L
Y
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.7
95.7
N.A.
93.3
92.7
N.A.
N.A.
85.1
80.9
77.8
N.A.
47.2
51.2
N.A.
56.3
Protein Similarity:
100
99.7
99.3
97.3
N.A.
96
95.8
N.A.
N.A.
91.6
89.5
86.7
N.A.
64.6
69.2
N.A.
70.6
P-Site Identity:
100
100
100
73.3
N.A.
80
86.6
N.A.
N.A.
6.6
13.3
26.6
N.A.
20
6.6
N.A.
0
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
N.A.
26.6
46.6
46.6
N.A.
40
20
N.A.
26.6
Percent
Protein Identity:
N.A.
33.5
N.A.
34.5
35.1
N.A.
Protein Similarity:
N.A.
46.8
N.A.
47.5
51
N.A.
P-Site Identity:
N.A.
13.3
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
6.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
14
14
0
34
0
0
14
0
7
0
14
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
14
20
0
0
7
27
20
0
7
0
0
0
7
0
% D
% Glu:
7
7
0
0
14
0
20
0
7
14
0
0
0
0
0
% E
% Phe:
7
0
0
0
0
0
0
0
0
7
7
0
0
0
20
% F
% Gly:
0
7
0
7
0
14
0
0
0
0
0
7
0
40
7
% G
% His:
0
0
0
0
0
7
0
0
7
0
0
0
0
7
0
% H
% Ile:
0
0
0
7
0
7
0
0
0
7
0
0
0
0
7
% I
% Lys:
0
0
0
0
0
0
14
0
0
34
0
0
7
0
0
% K
% Leu:
0
7
0
7
0
20
7
14
14
7
0
7
54
7
60
% L
% Met:
0
0
0
0
0
0
7
0
0
0
7
0
7
7
0
% M
% Asn:
0
14
47
7
0
0
7
14
0
7
7
14
0
0
0
% N
% Pro:
47
0
7
0
7
0
7
0
7
0
7
7
0
0
0
% P
% Gln:
7
40
0
0
0
0
0
14
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
7
0
0
0
7
7
0
0
0
7
0
% R
% Ser:
20
7
7
40
7
7
7
7
40
7
0
54
7
14
0
% S
% Thr:
0
0
7
14
47
0
7
27
0
7
14
14
7
0
0
% T
% Val:
7
0
0
7
14
7
0
7
0
0
54
0
0
7
7
% V
% Trp:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
0
0
0
0
7
0
0
0
7
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _