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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCR
All Species:
19.7
Human Site:
T389
Identified Species:
30.95
UniProt:
P04035
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P04035
NP_000850.1
888
97476
T389
C
D
S
V
E
E
E
T
G
I
N
R
E
R
K
Chimpanzee
Pan troglodytes
XP_001148324
888
97313
T389
C
D
S
V
E
E
E
T
G
I
N
R
E
R
K
Rhesus Macaque
Macaca mulatta
XP_001104607
888
97210
T389
C
D
S
I
E
E
E
T
G
I
N
R
E
R
K
Dog
Lupus familis
XP_536323
888
97475
T389
V
H
A
A
E
E
E
T
R
I
N
R
E
R
K
Cat
Felis silvestris
Mouse
Mus musculus
Q01237
887
97003
P389
L
S
S
V
E
E
D
P
G
A
N
Q
E
R
K
Rat
Rattus norvegicus
P51639
887
96670
P389
L
S
S
V
E
E
D
P
G
V
N
Q
D
R
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_989816
875
95421
F379
N
N
T
V
E
E
A
F
V
A
K
D
G
N
A
Frog
Xenopus laevis
P20715
883
96702
T385
E
K
T
V
H
V
S
T
T
E
E
A
S
S
K
Zebra Danio
Brachydanio rerio
NP_001119931
893
97691
E394
P
P
I
V
T
K
E
E
R
E
S
N
C
K
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P14773
920
98299
L433
S
A
A
V
R
T
L
L
F
T
I
E
D
Q
S
Honey Bee
Apis mellifera
XP_623118
908
99432
S391
E
N
E
D
M
N
F
S
F
L
T
T
K
M
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
P16393
932
100947
S390
S
D
V
R
V
I
E
S
M
T
S
R
T
Q
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O24594
579
60912
P136
Q
H
A
Q
A
P
A
P
C
E
L
L
G
S
P
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P14891
592
63579
T149
L
V
T
C
S
P
P
T
P
I
V
S
V
A
K
Baker's Yeast
Sacchar. cerevisiae
P12683
1054
115607
S542
K
T
E
V
T
K
K
S
F
T
A
P
V
Q
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.7
95.7
N.A.
93.3
92.7
N.A.
N.A.
85.1
80.9
77.8
N.A.
47.2
51.2
N.A.
56.3
Protein Similarity:
100
99.7
99.3
97.3
N.A.
96
95.8
N.A.
N.A.
91.6
89.5
86.7
N.A.
64.6
69.2
N.A.
70.6
P-Site Identity:
100
100
93.3
66.6
N.A.
60
53.3
N.A.
N.A.
20
20
13.3
N.A.
6.6
0
N.A.
20
P-Site Similarity:
100
100
100
73.3
N.A.
73.3
80
N.A.
N.A.
33.3
26.6
33.3
N.A.
26.6
26.6
N.A.
40
Percent
Protein Identity:
N.A.
33.5
N.A.
34.5
35.1
N.A.
Protein Similarity:
N.A.
46.8
N.A.
47.5
51
N.A.
P-Site Identity:
N.A.
0
N.A.
20
13.3
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
26.6
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
20
7
7
0
14
0
0
14
7
7
0
7
14
% A
% Cys:
20
0
0
7
0
0
0
0
7
0
0
0
7
0
0
% C
% Asp:
0
27
0
7
0
0
14
0
0
0
0
7
14
0
0
% D
% Glu:
14
0
14
0
47
47
40
7
0
20
7
7
34
0
0
% E
% Phe:
0
0
0
0
0
0
7
7
20
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
34
0
0
0
14
0
0
% G
% His:
0
14
0
0
7
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
7
7
0
7
0
0
0
34
7
0
0
0
0
% I
% Lys:
7
7
0
0
0
14
7
0
0
0
7
0
7
7
60
% K
% Leu:
20
0
0
0
0
0
7
7
0
7
7
7
0
0
0
% L
% Met:
0
0
0
0
7
0
0
0
7
0
0
0
0
7
0
% M
% Asn:
7
14
0
0
0
7
0
0
0
0
40
7
0
7
0
% N
% Pro:
7
7
0
0
0
14
7
20
7
0
0
7
0
0
14
% P
% Gln:
7
0
0
7
0
0
0
0
0
0
0
14
0
20
0
% Q
% Arg:
0
0
0
7
7
0
0
0
14
0
0
34
0
40
0
% R
% Ser:
14
14
34
0
7
0
7
20
0
0
14
7
7
14
14
% S
% Thr:
0
7
20
0
14
7
0
40
7
20
7
7
7
0
0
% T
% Val:
7
7
7
60
7
7
0
0
7
7
7
0
14
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _