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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGCR All Species: 51.21
Human Site: Y519 Identified Species: 80.48
UniProt: P04035 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P04035 NP_000850.1 888 97476 Y519 L P Y R D Y N Y S L V M G A C
Chimpanzee Pan troglodytes XP_001148324 888 97313 Y519 L P Y R D Y N Y S L V M G A C
Rhesus Macaque Macaca mulatta XP_001104607 888 97210 Y519 L P Y R D Y N Y S L V M G A C
Dog Lupus familis XP_536323 888 97475 Y519 L P Y R D Y N Y S L V M G A C
Cat Felis silvestris
Mouse Mus musculus Q01237 887 97003 Y518 L P Y R D Y N Y S L V M G A C
Rat Rattus norvegicus P51639 887 96670 Y518 L P Y R D Y N Y S L V M G A C
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_989816 875 95421 Y506 L P Y R N Y N Y S L V L G A C
Frog Xenopus laevis P20715 883 96702 Y514 L P Y K N Y N Y S L V M G A C
Zebra Danio Brachydanio rerio NP_001119931 893 97691 Y524 L P Y K D Y D Y S K V M G T C
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P14773 920 98299 Y546 L P Y E H F D Y R K V L N A C
Honey Bee Apis mellifera XP_623118 908 99432 Y517 L P Y K D Y D Y S K V L G A C
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus P16393 932 100947 Y535 L P Y A S Y D Y S F V S G A C
Poplar Tree Populus trichocarpa
Maize Zea mays O24594 579 60912 T245 R F Y L P M A T T E G C L V A
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P14891 592 63579 S258 L L D G Y E Y S V P M A T T E
Baker's Yeast Sacchar. cerevisiae P12683 1054 115607 Y674 L P Y K N Y D Y D R V F G A C
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 98.7 95.7 N.A. 93.3 92.7 N.A. N.A. 85.1 80.9 77.8 N.A. 47.2 51.2 N.A. 56.3
Protein Similarity: 100 99.7 99.3 97.3 N.A. 96 95.8 N.A. N.A. 91.6 89.5 86.7 N.A. 64.6 69.2 N.A. 70.6
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. N.A. 86.6 86.6 73.3 N.A. 46.6 73.3 N.A. 66.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 100 100 86.6 N.A. 66.6 93.3 N.A. 73.3
Percent
Protein Identity: N.A. 33.5 N.A. 34.5 35.1 N.A.
Protein Similarity: N.A. 46.8 N.A. 47.5 51 N.A.
P-Site Identity: N.A. 6.6 N.A. 6.6 60 N.A.
P-Site Similarity: N.A. 13.3 N.A. 13.3 80 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 7 0 0 7 0 0 0 0 7 0 80 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 87 % C
% Asp: 0 0 7 0 54 0 34 0 7 0 0 0 0 0 0 % D
% Glu: 0 0 0 7 0 7 0 0 0 7 0 0 0 0 7 % E
% Phe: 0 7 0 0 0 7 0 0 0 7 0 7 0 0 0 % F
% Gly: 0 0 0 7 0 0 0 0 0 0 7 0 80 0 0 % G
% His: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 27 0 0 0 0 0 20 0 0 0 0 0 % K
% Leu: 94 7 0 7 0 0 0 0 0 54 0 20 7 0 0 % L
% Met: 0 0 0 0 0 7 0 0 0 0 7 54 0 0 0 % M
% Asn: 0 0 0 0 20 0 54 0 0 0 0 0 7 0 0 % N
% Pro: 0 87 0 0 7 0 0 0 0 7 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 7 0 0 47 0 0 0 0 7 7 0 0 0 0 0 % R
% Ser: 0 0 0 0 7 0 0 7 74 0 0 7 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 7 7 0 0 0 7 14 0 % T
% Val: 0 0 0 0 0 0 0 0 7 0 87 0 0 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 94 0 7 80 7 87 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _