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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGCR All Species: 38.18
Human Site: Y644 Identified Species: 60
UniProt: P04035 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P04035 NP_000850.1 888 97476 Y644 S I A G R N L Y I R F Q S R S
Chimpanzee Pan troglodytes XP_001148324 888 97313 Y644 S I A G R N L Y I R F Q S R S
Rhesus Macaque Macaca mulatta XP_001104607 888 97210 Y644 S I A G R N L Y I R F Q S R S
Dog Lupus familis XP_536323 888 97475 Y644 S M A G R N L Y I R F Q S R S
Cat Felis silvestris
Mouse Mus musculus Q01237 887 97003 Y643 T M A G R N L Y I R F Q S R T
Rat Rattus norvegicus P51639 887 96670 Y643 T L A G R N L Y I R L Q S K T
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_989816 875 95421 Y631 S L A G R N L Y I R F Q S K T
Frog Xenopus laevis P20715 883 96702 Y639 C V A G R N L Y I R F Q S K T
Zebra Danio Brachydanio rerio NP_001119931 893 97691 Y649 G L A S R N L Y I R F Q S R T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P14773 920 98299 Y670 A M D G P Q L Y I R F V A I T
Honey Bee Apis mellifera XP_623118 908 99432 F641 R I A G R H L F I R F V A T T
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus P16393 932 100947 F660 A L A G R Y M F L R F K A L T
Poplar Tree Populus trichocarpa
Maize Zea mays O24594 579 60912 D361 N V L D F L Q D D F H D M D V
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P14891 592 63579 L374 S K G V Q N V L E Y L T D D F
Baker's Yeast Sacchar. cerevisiae P12683 1054 115607 F799 C L A G D L L F M R F R T T T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 98.7 95.7 N.A. 93.3 92.7 N.A. N.A. 85.1 80.9 77.8 N.A. 47.2 51.2 N.A. 56.3
Protein Similarity: 100 99.7 99.3 97.3 N.A. 96 95.8 N.A. N.A. 91.6 89.5 86.7 N.A. 64.6 69.2 N.A. 70.6
P-Site Identity: 100 100 100 93.3 N.A. 80 66.6 N.A. N.A. 80 73.3 73.3 N.A. 40 53.3 N.A. 33.3
P-Site Similarity: 100 100 100 100 N.A. 100 93.3 N.A. N.A. 100 93.3 86.6 N.A. 66.6 80 N.A. 86.6
Percent
Protein Identity: N.A. 33.5 N.A. 34.5 35.1 N.A.
Protein Similarity: N.A. 46.8 N.A. 47.5 51 N.A.
P-Site Identity: N.A. 0 N.A. 13.3 33.3 N.A.
P-Site Similarity: N.A. 13.3 N.A. 26.6 73.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 14 0 80 0 0 0 0 0 0 0 0 0 20 0 0 % A
% Cys: 14 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 7 7 7 0 0 7 7 0 0 7 7 14 0 % D
% Glu: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 7 0 0 20 0 7 80 0 0 0 7 % F
% Gly: 7 0 7 80 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 7 0 0 0 0 7 0 0 0 0 % H
% Ile: 0 27 0 0 0 0 0 0 74 0 0 0 0 7 0 % I
% Lys: 0 7 0 0 0 0 0 0 0 0 0 7 0 20 0 % K
% Leu: 0 34 7 0 0 14 80 7 7 0 14 0 0 7 0 % L
% Met: 0 20 0 0 0 0 7 0 7 0 0 0 7 0 0 % M
% Asn: 7 0 0 0 0 67 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 7 7 7 0 0 0 0 60 0 0 0 % Q
% Arg: 7 0 0 0 74 0 0 0 0 87 0 7 0 40 0 % R
% Ser: 40 0 0 7 0 0 0 0 0 0 0 0 60 0 27 % S
% Thr: 14 0 0 0 0 0 0 0 0 0 0 7 7 14 60 % T
% Val: 0 14 0 7 0 0 7 0 0 0 0 14 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 7 0 67 0 7 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _