KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCR
All Species:
46.67
Human Site:
Y792
Identified Species:
73.33
UniProt:
P04035
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P04035
NP_000850.1
888
97476
Y792
G
P
T
N
E
D
L
Y
I
S
C
T
M
P
S
Chimpanzee
Pan troglodytes
XP_001148324
888
97313
Y792
G
P
T
N
E
D
L
Y
I
S
C
T
M
P
S
Rhesus Macaque
Macaca mulatta
XP_001104607
888
97210
Y792
G
P
T
N
E
D
L
Y
I
S
C
T
M
P
S
Dog
Lupus familis
XP_536323
888
97475
Y792
G
P
T
N
E
D
L
Y
I
S
C
T
M
P
S
Cat
Felis silvestris
Mouse
Mus musculus
Q01237
887
97003
Y791
G
P
T
N
E
D
L
Y
I
S
C
T
M
P
S
Rat
Rattus norvegicus
P51639
887
96670
Y791
G
P
T
N
E
D
L
Y
I
S
C
T
M
P
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_989816
875
95421
Y779
C
S
T
S
E
D
L
Y
I
S
C
T
M
P
S
Frog
Xenopus laevis
P20715
883
96702
Y787
G
P
T
Y
E
D
L
Y
I
S
C
T
M
P
S
Zebra Danio
Brachydanio rerio
NP_001119931
893
97691
Y797
G
A
T
G
E
D
L
Y
I
S
C
T
M
P
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P14773
920
98299
Y818
A
E
N
S
E
D
L
Y
M
T
C
T
M
P
S
Honey Bee
Apis mellifera
XP_623118
908
99432
Y789
G
T
D
G
S
D
L
Y
V
S
C
T
M
P
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
P16393
932
100947
Y808
G
P
K
G
G
D
L
Y
L
S
C
T
M
P
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O24594
579
60912
L505
L
A
S
Q
S
A
C
L
D
L
L
G
V
R
G
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P14891
592
63579
S518
G
G
G
T
Q
L
A
S
Q
S
A
C
L
N
L
Baker's Yeast
Sacchar. cerevisiae
P12683
1054
115607
V949
D
G
D
L
R
I
S
V
S
M
P
S
I
E
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.7
95.7
N.A.
93.3
92.7
N.A.
N.A.
85.1
80.9
77.8
N.A.
47.2
51.2
N.A.
56.3
Protein Similarity:
100
99.7
99.3
97.3
N.A.
96
95.8
N.A.
N.A.
91.6
89.5
86.7
N.A.
64.6
69.2
N.A.
70.6
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
80
93.3
86.6
N.A.
60
66.6
N.A.
73.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
86.6
93.3
86.6
N.A.
80
73.3
N.A.
80
Percent
Protein Identity:
N.A.
33.5
N.A.
34.5
35.1
N.A.
Protein Similarity:
N.A.
46.8
N.A.
47.5
51
N.A.
P-Site Identity:
N.A.
0
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
26.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
14
0
0
0
7
7
0
0
0
7
0
0
0
0
% A
% Cys:
7
0
0
0
0
0
7
0
0
0
80
7
0
0
0
% C
% Asp:
7
0
14
0
0
80
0
0
7
0
0
0
0
0
0
% D
% Glu:
0
7
0
0
67
0
0
0
0
0
0
0
0
7
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
74
14
7
20
7
0
0
0
0
0
0
7
0
0
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
7
0
0
60
0
0
0
7
0
0
% I
% Lys:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
7
0
0
7
0
7
80
7
7
7
7
0
7
0
7
% L
% Met:
0
0
0
0
0
0
0
0
7
7
0
0
80
0
0
% M
% Asn:
0
0
7
40
0
0
0
0
0
0
0
0
0
7
0
% N
% Pro:
0
54
0
0
0
0
0
0
0
0
7
0
0
80
0
% P
% Gln:
0
0
0
7
7
0
0
0
7
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
7
0
0
0
0
0
0
0
0
7
0
% R
% Ser:
0
7
7
14
14
0
7
7
7
80
0
7
0
0
80
% S
% Thr:
0
7
60
7
0
0
0
0
0
7
0
80
0
0
0
% T
% Val:
0
0
0
0
0
0
0
7
7
0
0
0
7
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
7
0
0
0
80
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _