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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RAF1
All Species:
44.24
Human Site:
Y458
Identified Species:
88.48
UniProt:
P04049
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P04049
NP_002871.1
648
73052
Y458
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
I
I
Chimpanzee
Pan troglodytes
XP_001155232
648
73032
Y458
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
I
I
Rhesus Macaque
Macaca mulatta
XP_001086034
615
69495
Y425
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
I
I
Dog
Lupus familis
XP_859234
648
72974
Y458
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
I
I
Cat
Felis silvestris
Mouse
Mus musculus
Q99N57
648
72899
Y458
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
I
I
Rat
Rattus norvegicus
P11345
648
72910
Y458
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
I
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P05625
647
73106
Y458
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
I
I
Frog
Xenopus laevis
P09560
638
71941
Y449
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
I
I
Zebra Danio
Brachydanio rerio
NP_571514
643
72503
Y454
Q
T
A
Q
G
M
D
Y
L
Y
M
R
K
H
I
Tiger Blowfish
Takifugu rubipres
NP_001033078
663
74935
Y474
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
I
I
Fruit Fly
Dros. melanogaster
P11346
782
88616
Y581
Q
V
A
Q
G
M
D
Y
L
H
A
K
N
I
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q07292
813
90389
M590
L
K
Q
V
S
L
G
M
N
Y
L
H
S
K
N
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
94.9
98.7
N.A.
97.6
98.3
N.A.
N.A.
94.5
85.3
75.1
80.5
37.4
N.A.
36
N.A.
Protein Similarity:
100
100
94.9
99.2
N.A.
98.3
98.4
N.A.
N.A.
97.6
90.7
83.9
87
52.9
N.A.
51
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
100
66.6
100
93.3
N.A.
0
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
100
80
100
93.3
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
92
0
0
0
0
0
0
0
84
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
92
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
92
0
9
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
84
0
9
0
9
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
84
92
% I
% Lys:
0
9
0
0
0
0
0
0
0
0
0
84
9
9
0
% K
% Leu:
9
0
0
0
0
9
0
0
92
0
9
0
0
0
0
% L
% Met:
0
0
0
0
0
92
0
9
0
0
9
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
9
0
0
0
84
0
9
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
92
0
9
92
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% R
% Ser:
0
0
0
0
9
0
0
0
0
0
0
0
9
0
0
% S
% Thr:
0
84
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
9
0
9
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
92
0
17
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _