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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DNTT All Species: 44.55
Human Site: Y246 Identified Species: 89.09
UniProt: P04053 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P04053 NP_001017520.1 509 58437 Y246 A V L N D E R Y Q S F K L F T
Chimpanzee Pan troglodytes XP_521569 509 58461 Y246 A V L N D E R Y Q S F K L F T
Rhesus Macaque Macaca mulatta XP_001100878 510 58547 Y246 A V L N D E R Y Q S F K L F T
Dog Lupus familis XP_849761 510 58444 Y247 A V L N D E R Y Q S F K L F T
Cat Felis silvestris
Mouse Mus musculus P09838 530 60313 Y246 A V L N D E R Y K S F K L F T
Rat Rattus norvegicus NP_001012479 510 58470 Y246 A V L N D E R Y K S F K L F T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505901 514 59196 Y243 A V L N D E R Y R S F Q L F N
Chicken Gallus gallus P36195 506 58429 Y246 D V L N D E R Y K S F K E F T
Frog Xenopus laevis P42118 507 58827 Y242 E V M N E E R Y K S F K Q F T
Zebra Danio Brachydanio rerio NP_001014817 487 55201 Y233 E I Q N D Q R Y R T M K L F C
Tiger Blowfish Takifugu rubipres NP_001027915 498 56663 Y235 K V L S D E R Y Q T L K L F T
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796033 573 64326 Y249 G I K R S D W Y Q N M S L F T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.2 85.8 N.A. 77.9 82.5 N.A. 68.2 63.6 58.9 46.5 47.1 N.A. N.A. N.A. 36.1
Protein Similarity: 100 99.8 98.2 91.5 N.A. 85.2 89.6 N.A. 79.9 78.1 77.8 65.8 67.7 N.A. N.A. N.A. 52.1
P-Site Identity: 100 100 100 100 N.A. 93.3 93.3 N.A. 80 80 66.6 46.6 73.3 N.A. N.A. N.A. 33.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 93.3 86.6 86.6 73.3 86.6 N.A. N.A. N.A. 53.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 59 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % C
% Asp: 9 0 0 0 84 9 0 0 0 0 0 0 0 0 0 % D
% Glu: 17 0 0 0 9 84 0 0 0 0 0 0 9 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 75 0 0 100 0 % F
% Gly: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 17 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 9 0 9 0 0 0 0 0 34 0 0 84 0 0 0 % K
% Leu: 0 0 75 0 0 0 0 0 0 0 9 0 84 0 0 % L
% Met: 0 0 9 0 0 0 0 0 0 0 17 0 0 0 0 % M
% Asn: 0 0 0 84 0 0 0 0 0 9 0 0 0 0 9 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 9 0 0 9 0 0 50 0 0 9 9 0 0 % Q
% Arg: 0 0 0 9 0 0 92 0 17 0 0 0 0 0 0 % R
% Ser: 0 0 0 9 9 0 0 0 0 75 0 9 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 17 0 0 0 0 84 % T
% Val: 0 84 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _