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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ASL All Species: 11.52
Human Site: T131 Identified Species: 23.03
UniProt: P04424 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P04424 NP_000039.2 464 51658 T131 W M R Q T C S T L S G L L W E
Chimpanzee Pan troglodytes XP_519125 616 66967 T283 W M R Q T C S T L S G L L W E
Rhesus Macaque Macaca mulatta XP_001087106 489 54426 T161 W M R Q T C S T L S G L L W E
Dog Lupus familis XP_536832 464 51774 R131 W M R Q D C S R L S A L L W E
Cat Felis silvestris
Mouse Mus musculus Q91YI0 464 51721 K131 W M R Q T C S K L S A L L R V
Rat Rattus norvegicus P20673 461 51531 K131 W M R Q T Y S K L S T F L K V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P05083 466 51025 V131 L L K S S I S V I S T H L L Q
Frog Xenopus laevis NP_001087626 443 49451 D120 R N D Q V V T D M R L W L R D
Zebra Danio Brachydanio rerio XP_002666083 465 52089 T132 W L R D G I A T L K E L A L Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_624062 461 52688 V131 W L R K A I D V L L K K L M K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_780183 575 64473 C244 W L R D S L E C M Y P M V K N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P04076 463 51971 D132 Y C R D I V N D T L F P A L K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 75 84.8 93.5 N.A. 93.9 89 N.A. N.A. 69.5 69.1 70.5 N.A. N.A. 52.1 N.A. 52.7
Protein Similarity: 100 75 87.9 96.5 N.A. 95.6 91.8 N.A. N.A. 85.4 82.5 84.9 N.A. N.A. 70.4 N.A. 64.3
P-Site Identity: 100 100 100 80 N.A. 73.3 60 N.A. N.A. 20 13.3 33.3 N.A. N.A. 26.6 N.A. 13.3
P-Site Similarity: 100 100 100 80 N.A. 73.3 60 N.A. N.A. 53.3 33.3 53.3 N.A. N.A. 46.6 N.A. 46.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 54.3 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 72.4 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 9 0 9 0 0 0 17 0 17 0 0 % A
% Cys: 0 9 0 0 0 42 0 9 0 0 0 0 0 0 0 % C
% Asp: 0 0 9 25 9 0 9 17 0 0 0 0 0 0 9 % D
% Glu: 0 0 0 0 0 0 9 0 0 0 9 0 0 0 34 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 9 9 0 0 0 % F
% Gly: 0 0 0 0 9 0 0 0 0 0 25 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % H
% Ile: 0 0 0 0 9 25 0 0 9 0 0 0 0 0 0 % I
% Lys: 0 0 9 9 0 0 0 17 0 9 9 9 0 17 17 % K
% Leu: 9 34 0 0 0 9 0 0 67 17 9 50 75 25 0 % L
% Met: 0 50 0 0 0 0 0 0 17 0 0 9 0 9 0 % M
% Asn: 0 9 0 0 0 0 9 0 0 0 0 0 0 0 9 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 9 9 0 0 0 % P
% Gln: 0 0 0 59 0 0 0 0 0 0 0 0 0 0 17 % Q
% Arg: 9 0 84 0 0 0 0 9 0 9 0 0 0 17 0 % R
% Ser: 0 0 0 9 17 0 59 0 0 59 0 0 0 0 0 % S
% Thr: 0 0 0 0 42 0 9 34 9 0 17 0 0 0 0 % T
% Val: 0 0 0 0 9 17 0 17 0 0 0 0 9 0 17 % V
% Trp: 75 0 0 0 0 0 0 0 0 0 0 9 0 34 0 % W
% Tyr: 9 0 0 0 0 9 0 0 0 9 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _