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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ASL All Species: 40.91
Human Site: Y375 Identified Species: 81.82
UniProt: P04424 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P04424 NP_000039.2 464 51658 Y375 M L A T D L A Y Y L V R K G M
Chimpanzee Pan troglodytes XP_519125 616 66967 Y527 M L A T D L A Y Y L V R K G M
Rhesus Macaque Macaca mulatta XP_001087106 489 54426 Y400 M L A T D L A Y Y L V R K G M
Dog Lupus familis XP_536832 464 51774 Y375 M L A T D L A Y Y L V R K G M
Cat Felis silvestris
Mouse Mus musculus Q91YI0 464 51721 Y375 M L A T D L A Y Y L V R K G M
Rat Rattus norvegicus P20673 461 51531 Y375 M L A T D L A Y Y L V R K G M
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P05083 466 51025 L375 L L S T D L A L Y L V R K G M
Frog Xenopus laevis NP_001087626 443 49451 Y354 M L S T D I A Y Y L V R K G M
Zebra Danio Brachydanio rerio XP_002666083 465 52089 Y376 M L A T D L A Y H L V R K G M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_624062 461 52688 Y375 M L A T D M A Y Y L V R K G I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_780183 575 64473 Y488 M L S T D L A Y Y L V R K G V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P04076 463 51971 D377 M L A T D L A D Y L V R K G V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 75 84.8 93.5 N.A. 93.9 89 N.A. N.A. 69.5 69.1 70.5 N.A. N.A. 52.1 N.A. 52.7
Protein Similarity: 100 75 87.9 96.5 N.A. 95.6 91.8 N.A. N.A. 85.4 82.5 84.9 N.A. N.A. 70.4 N.A. 64.3
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. N.A. 80 86.6 93.3 N.A. N.A. 86.6 N.A. 86.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 93.3 100 100 N.A. N.A. 100 N.A. 100
Percent
Protein Identity: N.A. N.A. N.A. N.A. 54.3 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 72.4 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 86.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 93.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 75 0 0 0 100 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 100 0 0 9 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 % G
% His: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 9 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 % K
% Leu: 9 100 0 0 0 84 0 9 0 100 0 0 0 0 0 % L
% Met: 92 0 0 0 0 9 0 0 0 0 0 0 0 0 75 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 % R
% Ser: 0 0 25 0 0 0 0 0 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 100 0 0 0 17 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 84 92 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _