Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: WNT1 All Species: 22.12
Human Site: Y258 Identified Species: 40.56
UniProt: P04628 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P04628 NP_005421.1 370 40982 Y258 D G A S R V L Y G N R G S N R
Chimpanzee Pan troglodytes XP_523686 423 47308 V314 D S A S E M V V E K H R E S R
Rhesus Macaque Macaca mulatta XP_001105191 370 40978 Y258 D G A S R V L Y G N R G S N R
Dog Lupus familis XP_543686 611 66494 Y499 D G A S R V L Y G N R G S N R
Cat Felis silvestris
Mouse Mus musculus P04426 370 41067 Y258 D G A S R V L Y G N R G S N R
Rat Rattus norvegicus Q9QXQ5 351 39025 G240 A L K E K F D G A T E V E P R
Wallaby Macropus eugenll
Platypus Ornith. anatinus Q07DZ8 361 40096 Y239 G D Y L W R K Y N G A I Q V V
Chicken Gallus gallus Q2LMP1 352 39611 V243 D S A S E M V V E K H R E S R
Frog Xenopus laevis P10108 371 41107 Y258 D G A S K V T Y S N N G S N R
Zebra Danio Brachydanio rerio P24257 370 40992 Y257 D G A S R V V Y A N K G S N R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P09615 468 51968 V273 D G A T R V Q V T N S L R A T
Honey Bee Apis mellifera XP_396946 412 46385 V277 D G A S R V M V S N S D R V R
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus P28094 223 25218 S117 V T M R N D G S P S D R E T E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 40.4 99.7 60.3 N.A. 98.9 44.3 N.A. 43.2 42.1 69.8 75.9 N.A. 44.4 53.4 N.A. 38.1
Protein Similarity: 100 55 99.7 60.3 N.A. 99.1 58.6 N.A. 60.8 58.6 83.8 88.6 N.A. 55.7 65 N.A. 44.8
P-Site Identity: 100 26.6 100 100 N.A. 100 6.6 N.A. 6.6 26.6 73.3 80 N.A. 40 53.3 N.A. 0
P-Site Similarity: 100 46.6 100 100 N.A. 100 13.3 N.A. 6.6 46.6 80 93.3 N.A. 46.6 60 N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 77 0 0 0 0 0 16 0 8 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 77 8 0 0 0 8 8 0 0 0 8 8 0 0 0 % D
% Glu: 0 0 0 8 16 0 0 0 16 0 8 0 31 0 8 % E
% Phe: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 62 0 0 0 0 8 8 31 8 0 47 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 16 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % I
% Lys: 0 0 8 0 16 0 8 0 0 16 8 0 0 0 0 % K
% Leu: 0 8 0 8 0 0 31 0 0 0 0 8 0 0 0 % L
% Met: 0 0 8 0 0 16 8 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 8 0 0 0 8 62 8 0 0 47 0 % N
% Pro: 0 0 0 0 0 0 0 0 8 0 0 0 0 8 0 % P
% Gln: 0 0 0 0 0 0 8 0 0 0 0 0 8 0 0 % Q
% Arg: 0 0 0 8 54 8 0 0 0 0 31 24 16 0 77 % R
% Ser: 0 16 0 70 0 0 0 8 16 8 16 0 47 16 0 % S
% Thr: 0 8 0 8 0 0 8 0 8 8 0 0 0 8 8 % T
% Val: 8 0 0 0 0 62 24 31 0 0 0 8 0 16 8 % V
% Trp: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 0 0 0 54 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _