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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: WNT1 All Species: 41.82
Human Site: Y291 Identified Species: 76.67
UniProt: P04628 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P04628 NP_005421.1 370 40982 Y291 P S P H D L V Y F E K S P N F
Chimpanzee Pan troglodytes XP_523686 423 47308 Y344 P T E R D L V Y Y E N S P N F
Rhesus Macaque Macaca mulatta XP_001105191 370 40978 Y291 P S P H D L V Y F E K S P N F
Dog Lupus familis XP_543686 611 66494 Y532 P S P H D L V Y F E K S P N F
Cat Felis silvestris
Mouse Mus musculus P04426 370 41067 Y291 P S P H D L V Y F E K S P N F
Rat Rattus norvegicus Q9QXQ5 351 39025 Y272 H T D E D L V Y L E P S P D F
Wallaby Macropus eugenll
Platypus Ornith. anatinus Q07DZ8 361 40096 Y271 P T K N D L V Y F E N S P D Y
Chicken Gallus gallus Q2LMP1 352 39611 Y273 P T E K D L V Y Y E N S P N F
Frog Xenopus laevis P10108 371 41107 Y292 P S S Q D L V Y F E K S P N F
Zebra Danio Brachydanio rerio P24257 370 40992 Y291 P S S R D L V Y F E K S P N F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P09615 468 51968 Y389 P G S K D L V Y L E P S P S F
Honey Bee Apis mellifera XP_396946 412 46385 Y333 P G P K D L V Y L E P S P P F
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus P28094 223 25218 N147 R D L V Y F E N S P D F C E R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 40.4 99.7 60.3 N.A. 98.9 44.3 N.A. 43.2 42.1 69.8 75.9 N.A. 44.4 53.4 N.A. 38.1
Protein Similarity: 100 55 99.7 60.3 N.A. 99.1 58.6 N.A. 60.8 58.6 83.8 88.6 N.A. 55.7 65 N.A. 44.8
P-Site Identity: 100 66.6 100 100 N.A. 100 53.3 N.A. 60 66.6 86.6 86.6 N.A. 60 66.6 N.A. 0
P-Site Similarity: 100 80 100 100 N.A. 100 66.6 N.A. 86.6 80 86.6 86.6 N.A. 66.6 66.6 N.A. 0
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % C
% Asp: 0 8 8 0 93 0 0 0 0 0 8 0 0 16 0 % D
% Glu: 0 0 16 8 0 0 8 0 0 93 0 0 0 8 0 % E
% Phe: 0 0 0 0 0 8 0 0 54 0 0 8 0 0 85 % F
% Gly: 0 16 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 8 0 0 31 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 8 24 0 0 0 0 0 0 47 0 0 0 0 % K
% Leu: 0 0 8 0 0 93 0 0 24 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 8 0 0 0 8 0 0 24 0 0 62 0 % N
% Pro: 85 0 39 0 0 0 0 0 0 8 24 0 93 8 0 % P
% Gln: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 8 0 0 16 0 0 0 0 0 0 0 0 0 0 8 % R
% Ser: 0 47 24 0 0 0 0 0 8 0 0 93 0 8 0 % S
% Thr: 0 31 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 8 0 0 93 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 0 0 93 16 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _