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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TYMS
All Species:
56.36
Human Site:
S114
Identified Species:
82.67
UniProt:
P04818
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P04818
NP_001062.1
313
35716
S114
K
I
W
D
A
N
G
S
R
D
F
L
D
S
L
Chimpanzee
Pan troglodytes
XP_001150437
313
35656
S114
K
I
W
D
A
N
G
S
R
D
F
L
D
S
L
Rhesus Macaque
Macaca mulatta
XP_001089274
313
35614
S114
K
I
W
D
A
N
G
S
R
D
F
L
D
S
L
Dog
Lupus familis
XP_533309
325
36767
S115
K
I
W
D
A
N
G
S
R
D
F
L
D
S
L
Cat
Felis silvestris
Mouse
Mus musculus
P07607
307
34940
S108
R
I
W
D
A
N
G
S
R
D
F
L
D
S
L
Rat
Rattus norvegicus
P45352
307
34999
S108
R
I
W
D
A
N
G
S
R
D
F
L
D
S
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508361
313
35234
S114
R
I
W
D
A
N
G
S
R
D
F
L
D
K
H
Chicken
Gallus gallus
XP_419147
298
34062
S99
K
I
W
D
A
N
G
S
R
E
F
L
D
K
Q
Frog
Xenopus laevis
NP_001096659
309
35145
S110
K
I
W
D
A
N
G
S
R
E
F
L
D
K
Q
Zebra Danio
Brachydanio rerio
NP_571835
319
36295
S120
R
I
W
D
A
N
G
S
R
E
F
L
D
K
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O76511
321
36638
S120
H
I
W
D
G
N
S
S
R
E
F
L
D
K
M
Honey Bee
Apis mellifera
XP_624369
305
35528
S106
H
I
W
D
A
N
S
S
R
E
F
L
D
S
C
Nematode Worm
Caenorhab. elegans
NP_491532
312
35434
D113
K
I
W
E
K
N
G
D
R
A
F
L
D
N
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O81395
521
58947
S322
H
I
W
D
G
N
A
S
R
E
Y
L
N
S
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q05763
565
63190
S366
R
I
W
D
G
N
A
S
R
A
Y
L
D
G
I
Baker's Yeast
Sacchar. cerevisiae
P06785
304
35029
S96
K
I
W
D
G
N
G
S
R
E
Y
L
D
K
M
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
97.7
84.6
N.A.
88.8
88.5
N.A.
82.4
81.1
79.5
74.9
N.A.
62.9
65.5
62.6
N.A.
Protein Similarity:
100
100
99
89.5
N.A.
93.6
93.2
N.A.
91
87.8
87.5
84.9
N.A.
76
77.9
73.8
N.A.
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
80
80
80
73.3
N.A.
60
73.3
66.6
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
86.6
86.6
86.6
86.6
N.A.
73.3
80
80
N.A.
Percent
Protein Identity:
N.A.
39.7
N.A.
37.1
60
N.A.
Protein Similarity:
N.A.
48.1
N.A.
44.4
73.8
N.A.
P-Site Identity:
N.A.
53.3
N.A.
53.3
66.6
N.A.
P-Site Similarity:
N.A.
80
N.A.
73.3
86.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
69
0
13
0
0
13
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% C
% Asp:
0
0
0
94
0
0
0
7
0
44
0
0
94
0
0
% D
% Glu:
0
0
0
7
0
0
0
0
0
44
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
82
0
0
0
0
% F
% Gly:
0
0
0
0
25
0
75
0
0
0
0
0
0
7
0
% G
% His:
19
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% H
% Ile:
0
100
0
0
0
0
0
0
0
0
0
0
0
0
7
% I
% Lys:
50
0
0
0
7
0
0
0
0
0
0
0
0
38
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
100
0
0
44
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
13
% M
% Asn:
0
0
0
0
0
100
0
0
0
0
0
0
7
7
7
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
13
% Q
% Arg:
32
0
0
0
0
0
0
0
100
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
13
94
0
0
0
0
0
50
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% V
% Trp:
0
0
100
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
19
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _