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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TYMS All Species: 40.3
Human Site: S124 Identified Species: 59.11
UniProt: P04818 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P04818 NP_001062.1 313 35716 S124 F L D S L G F S T R E E G D L
Chimpanzee Pan troglodytes XP_001150437 313 35656 S124 F L D S L G F S T R E E G D L
Rhesus Macaque Macaca mulatta XP_001089274 313 35614 S124 F L D S L G F S A R E E G D L
Dog Lupus familis XP_533309 325 36767 A125 F L D S L G F A N R E E G D L
Cat Felis silvestris
Mouse Mus musculus P07607 307 34940 S118 F L D S L G F S A R Q E G D L
Rat Rattus norvegicus P45352 307 34999 S118 F L D S L G F S A R Q E G D L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508361 313 35234 T124 F L D K H G F T S R E E G D L
Chicken Gallus gallus XP_419147 298 34062 C109 F L D K Q G F C T R E E G D L
Frog Xenopus laevis NP_001096659 309 35145 S120 F L D K Q G F S T R E E G D L
Zebra Danio Brachydanio rerio NP_571835 319 36295 T130 F L D K N G F T D R E E G D L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O76511 321 36638 T130 F L D K M G F T G R A V G D L
Honey Bee Apis mellifera XP_624369 305 35528 I116 F L D S C G F I D R E E G D L
Nematode Worm Caenorhab. elegans NP_491532 312 35434 T123 F L D N L G F T S R E E G D L
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays O81395 521 58947 A332 Y L N S V G L A H R E E G D L
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q05763 565 63190 T376 Y L D G I G L T E R E E G D L
Baker's Yeast Sacchar. cerevisiae P06785 304 35029 K106 Y L D K M G F K D R K V G D L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 97.7 84.6 N.A. 88.8 88.5 N.A. 82.4 81.1 79.5 74.9 N.A. 62.9 65.5 62.6 N.A.
Protein Similarity: 100 100 99 89.5 N.A. 93.6 93.2 N.A. 91 87.8 87.5 84.9 N.A. 76 77.9 73.8 N.A.
P-Site Identity: 100 100 93.3 86.6 N.A. 86.6 86.6 N.A. 73.3 80 86.6 73.3 N.A. 60 80 80 N.A.
P-Site Similarity: 100 100 93.3 93.3 N.A. 93.3 93.3 N.A. 86.6 80 86.6 80 N.A. 73.3 80 100 N.A.
Percent
Protein Identity: N.A. 39.7 N.A. 37.1 60 N.A.
Protein Similarity: N.A. 48.1 N.A. 44.4 73.8 N.A.
P-Site Identity: N.A. 60 N.A. 60 53.3 N.A.
P-Site Similarity: N.A. 86.6 N.A. 80 73.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 13 19 0 7 0 0 0 0 % A
% Cys: 0 0 0 0 7 0 0 7 0 0 0 0 0 0 0 % C
% Asp: 0 0 94 0 0 0 0 0 19 0 0 0 0 100 0 % D
% Glu: 0 0 0 0 0 0 0 0 7 0 75 88 0 0 0 % E
% Phe: 82 0 0 0 0 0 88 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 7 0 100 0 0 7 0 0 0 100 0 0 % G
% His: 0 0 0 0 7 0 0 0 7 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 7 0 0 7 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 38 0 0 0 7 0 0 7 0 0 0 0 % K
% Leu: 0 100 0 0 44 0 13 0 0 0 0 0 0 0 100 % L
% Met: 0 0 0 0 13 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 7 7 7 0 0 0 7 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 13 0 0 0 0 0 13 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 % R
% Ser: 0 0 0 50 0 0 0 38 13 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 32 25 0 0 0 0 0 0 % T
% Val: 0 0 0 0 7 0 0 0 0 0 0 13 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 19 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _