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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TYMS
All Species:
24.52
Human Site:
S6
Identified Species:
35.97
UniProt:
P04818
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P04818
NP_001062.1
313
35716
S6
_
_
M
P
V
A
G
S
E
L
P
R
R
P
L
Chimpanzee
Pan troglodytes
XP_001150437
313
35656
S6
_
_
M
P
V
A
G
S
E
L
P
R
R
P
L
Rhesus Macaque
Macaca mulatta
XP_001089274
313
35614
S6
_
_
M
P
V
A
G
S
E
L
P
R
P
P
L
Dog
Lupus familis
XP_533309
325
36767
S6
_
_
M
P
A
P
G
S
E
L
Q
R
P
P
S
Cat
Felis silvestris
Mouse
Mus musculus
P07607
307
34940
S6
_
_
M
L
V
V
G
S
E
L
Q
S
D
A
Q
Rat
Rattus norvegicus
P45352
307
34999
S6
_
_
M
L
V
E
G
S
E
L
Q
S
G
A
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508361
313
35234
P13
G
S
G
P
G
P
G
P
G
L
Q
Q
Q
Q
P
Chicken
Gallus gallus
XP_419147
298
34062
E6
_
_
M
P
A
A
E
E
P
S
S
G
L
E
G
Frog
Xenopus laevis
NP_001096659
309
35145
S11
I
S
E
S
T
A
A
S
S
C
P
E
Q
G
A
Zebra Danio
Brachydanio rerio
NP_571835
319
36295
V6
_
_
M
P
D
T
A
V
E
V
T
N
G
H
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O76511
321
36638
G22
M
P
L
P
A
D
N
G
E
S
P
S
K
Q
Q
Honey Bee
Apis mellifera
XP_624369
305
35528
S9
N
E
Y
E
I
I
T
S
Q
E
C
F
Q
N
E
Nematode Worm
Caenorhab. elegans
NP_491532
312
35434
S12
N
I
I
A
D
A
P
S
D
V
V
K
T
V
Q
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O81395
521
58947
S55
K
E
L
T
L
T
T
S
D
P
V
K
K
N
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q05763
565
63190
S103
K
D
L
T
L
S
T
S
D
S
A
K
K
N
A
Baker's Yeast
Sacchar. cerevisiae
P06785
304
35029
N7
_
M
T
M
D
G
K
N
K
E
E
E
Q
Y
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
97.7
84.6
N.A.
88.8
88.5
N.A.
82.4
81.1
79.5
74.9
N.A.
62.9
65.5
62.6
N.A.
Protein Similarity:
100
100
99
89.5
N.A.
93.6
93.2
N.A.
91
87.8
87.5
84.9
N.A.
76
77.9
73.8
N.A.
P-Site Identity:
100
100
92.3
61.5
N.A.
46.1
46.1
N.A.
20
23
20
23
N.A.
20
6.6
13.3
N.A.
P-Site Similarity:
100
100
92.3
61.5
N.A.
46.1
46.1
N.A.
40
23
33.3
30.7
N.A.
33.3
26.6
46.6
N.A.
Percent
Protein Identity:
N.A.
39.7
N.A.
37.1
60
N.A.
Protein Similarity:
N.A.
48.1
N.A.
44.4
73.8
N.A.
P-Site Identity:
N.A.
6.6
N.A.
6.6
7.1
N.A.
P-Site Similarity:
N.A.
40
N.A.
46.6
28.5
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
19
38
13
0
0
0
7
0
0
13
19
% A
% Cys:
0
0
0
0
0
0
0
0
0
7
7
0
0
0
7
% C
% Asp:
0
7
0
0
19
7
0
0
19
0
0
0
7
0
0
% D
% Glu:
0
13
7
7
0
7
7
7
50
13
7
13
0
7
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% F
% Gly:
7
0
7
0
7
7
44
7
7
0
0
7
13
7
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% H
% Ile:
7
7
7
0
7
7
0
0
0
0
0
0
0
0
0
% I
% Lys:
13
0
0
0
0
0
7
0
7
0
0
19
19
0
0
% K
% Leu:
0
0
19
13
13
0
0
0
0
44
0
0
7
0
25
% L
% Met:
7
7
50
7
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
13
0
0
0
0
0
7
7
0
0
0
7
0
19
0
% N
% Pro:
0
7
0
50
0
13
7
7
7
7
32
0
13
25
7
% P
% Gln:
0
0
0
0
0
0
0
0
7
0
25
7
25
13
25
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
25
13
0
0
% R
% Ser:
0
13
0
7
0
7
0
69
7
19
7
19
0
0
7
% S
% Thr:
0
0
7
13
7
13
19
0
0
0
7
0
7
0
0
% T
% Val:
0
0
0
0
32
7
0
7
0
13
13
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
0
0
0
0
0
0
0
0
7
0
% Y
% Spaces:
57
50
0
0
0
0
0
0
0
0
0
0
0
0
0
% _