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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TYMS
All Species:
52.73
Human Site:
T53
Identified Species:
77.33
UniProt:
P04818
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P04818
NP_001062.1
313
35716
T53
R
K
D
D
R
T
G
T
G
T
L
S
V
F
G
Chimpanzee
Pan troglodytes
XP_001150437
313
35656
T53
R
K
D
D
R
T
G
T
G
T
L
S
V
F
G
Rhesus Macaque
Macaca mulatta
XP_001089274
313
35614
T53
R
K
D
D
R
T
G
T
G
T
L
S
V
F
G
Dog
Lupus familis
XP_533309
325
36767
T54
R
K
H
D
R
T
G
T
G
T
L
S
V
F
G
Cat
Felis silvestris
Mouse
Mus musculus
P07607
307
34940
T47
K
K
E
D
R
T
G
T
G
T
L
S
V
F
G
Rat
Rattus norvegicus
P45352
307
34999
T47
K
K
E
D
R
T
G
T
G
T
L
S
V
F
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508361
313
35234
T53
K
K
E
D
R
T
G
T
G
T
V
S
V
F
G
Chicken
Gallus gallus
XP_419147
298
34062
T38
R
K
E
D
R
T
G
T
G
T
I
S
V
F
G
Frog
Xenopus laevis
NP_001096659
309
35145
T49
R
K
E
D
R
T
G
T
G
T
V
S
V
F
G
Zebra Danio
Brachydanio rerio
NP_571835
319
36295
T59
K
K
G
D
R
T
G
T
G
V
I
S
V
F
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O76511
321
36638
V59
Q
R
M
D
R
T
E
V
G
T
L
S
V
F
G
Honey Bee
Apis mellifera
XP_624369
305
35528
V44
R
K
D
D
R
T
G
V
G
T
L
S
I
F
G
Nematode Worm
Caenorhab. elegans
NP_491532
312
35434
T51
R
R
D
D
R
T
G
T
G
T
I
S
I
F
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O81395
521
58947
T261
Q
K
N
D
R
T
G
T
G
T
L
S
K
F
G
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q05763
565
63190
T305
L
K
D
D
R
T
G
T
G
T
L
S
K
F
G
Baker's Yeast
Sacchar. cerevisiae
P06785
304
35029
F39
G
T
G
T
L
S
L
F
A
P
P
Q
L
R
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
97.7
84.6
N.A.
88.8
88.5
N.A.
82.4
81.1
79.5
74.9
N.A.
62.9
65.5
62.6
N.A.
Protein Similarity:
100
100
99
89.5
N.A.
93.6
93.2
N.A.
91
87.8
87.5
84.9
N.A.
76
77.9
73.8
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
86.6
86.6
N.A.
80
86.6
86.6
73.3
N.A.
66.6
86.6
80
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
100
100
100
86.6
N.A.
80
93.3
100
N.A.
Percent
Protein Identity:
N.A.
39.7
N.A.
37.1
60
N.A.
Protein Similarity:
N.A.
48.1
N.A.
44.4
73.8
N.A.
P-Site Identity:
N.A.
80
N.A.
86.6
0
N.A.
P-Site Similarity:
N.A.
93.3
N.A.
86.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
38
94
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
32
0
0
0
7
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
7
0
0
0
0
0
94
7
% F
% Gly:
7
0
13
0
0
0
88
0
94
0
0
0
0
0
94
% G
% His:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
19
0
13
0
0
% I
% Lys:
25
82
0
0
0
0
0
0
0
0
0
0
13
0
0
% K
% Leu:
7
0
0
0
7
0
7
0
0
0
63
0
7
0
0
% L
% Met:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
7
7
0
0
0
0
% P
% Gln:
13
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% Q
% Arg:
50
13
0
0
94
0
0
0
0
0
0
0
0
7
0
% R
% Ser:
0
0
0
0
0
7
0
0
0
0
0
94
0
0
0
% S
% Thr:
0
7
0
7
0
94
0
82
0
88
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
13
0
7
13
0
69
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _