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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TYMS All Species: 53.03
Human Site: T75 Identified Species: 77.78
UniProt: P04818 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P04818 NP_001062.1 313 35716 T75 R D E F P L L T T K R V F W K
Chimpanzee Pan troglodytes XP_001150437 313 35656 T75 R D E F P L L T T K R V F W K
Rhesus Macaque Macaca mulatta XP_001089274 313 35614 T75 R D E F P L L T T K R V F W K
Dog Lupus familis XP_533309 325 36767 T76 R D E F P L L T T K R V F W K
Cat Felis silvestris
Mouse Mus musculus P07607 307 34940 T69 R D E F P L L T T K R V F W K
Rat Rattus norvegicus P45352 307 34999 T69 R D E F P L L T T K R V F W K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508361 313 35234 T75 R D Q F P L L T T K R V F W K
Chicken Gallus gallus XP_419147 298 34062 T60 R D Q F P L L T T K R V F W K
Frog Xenopus laevis NP_001096659 309 35145 T71 R D Q F P L L T T K R V F W K
Zebra Danio Brachydanio rerio NP_571835 319 36295 T81 R D Q F P L L T T K R V F W K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O76511 321 36638 T81 R N S F P L L T T K R V F F R
Honey Bee Apis mellifera XP_624369 305 35528 L66 R N N I F P L L T T K R V F W
Nematode Worm Caenorhab. elegans NP_491532 312 35434 L73 R N G T I P L L T T K R V Y W
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays O81395 521 58947 T283 R K N F P L L T T K R V F W R
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q05763 565 63190 T327 R R N F P L L T T K R V F W R
Baker's Yeast Sacchar. cerevisiae P06785 304 35029 V61 P L L T T K K V F T R G I I L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 97.7 84.6 N.A. 88.8 88.5 N.A. 82.4 81.1 79.5 74.9 N.A. 62.9 65.5 62.6 N.A.
Protein Similarity: 100 100 99 89.5 N.A. 93.6 93.2 N.A. 91 87.8 87.5 84.9 N.A. 76 77.9 73.8 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 93.3 93.3 93.3 93.3 N.A. 73.3 20 20 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 100 100 100 N.A. 93.3 40 40 N.A.
Percent
Protein Identity: N.A. 39.7 N.A. 37.1 60 N.A.
Protein Similarity: N.A. 48.1 N.A. 44.4 73.8 N.A.
P-Site Identity: N.A. 80 N.A. 80 6.6 N.A.
P-Site Similarity: N.A. 86.6 N.A. 86.6 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 63 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 38 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 82 7 0 0 0 7 0 0 0 82 13 0 % F
% Gly: 0 0 7 0 0 0 0 0 0 0 0 7 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 7 7 0 0 0 0 0 0 0 7 7 0 % I
% Lys: 0 7 0 0 0 7 7 0 0 82 13 0 0 0 63 % K
% Leu: 0 7 7 0 0 82 94 13 0 0 0 0 0 0 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 19 19 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 7 0 0 0 82 13 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 25 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 94 7 0 0 0 0 0 0 0 0 88 13 0 0 19 % R
% Ser: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 13 7 0 0 82 94 19 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 7 0 0 0 82 13 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 75 13 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _