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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TYMS
All Species:
61.21
Human Site:
Y146
Identified Species:
89.78
UniProt:
P04818
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P04818
NP_001062.1
313
35716
Y146
W
R
H
F
G
A
E
Y
R
D
M
E
S
D
Y
Chimpanzee
Pan troglodytes
XP_001150437
313
35656
Y146
W
R
H
F
G
A
E
Y
R
D
M
E
S
D
Y
Rhesus Macaque
Macaca mulatta
XP_001089274
313
35614
Y146
W
R
H
F
G
A
E
Y
R
D
M
E
S
D
Y
Dog
Lupus familis
XP_533309
325
36767
Y147
W
R
H
F
G
A
E
Y
K
D
K
D
S
D
Y
Cat
Felis silvestris
Mouse
Mus musculus
P07607
307
34940
Y140
W
R
H
F
G
A
E
Y
K
D
M
D
S
D
Y
Rat
Rattus norvegicus
P45352
307
34999
Y140
W
R
H
F
G
A
D
Y
K
D
M
D
S
D
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508361
313
35234
Y146
W
R
H
F
G
A
E
Y
K
E
M
N
T
D
Y
Chicken
Gallus gallus
XP_419147
298
34062
Y131
W
R
H
F
G
A
D
Y
K
D
M
H
T
D
Y
Frog
Xenopus laevis
NP_001096659
309
35145
Y142
W
R
H
F
G
A
E
Y
K
D
T
H
T
D
Y
Zebra Danio
Brachydanio rerio
NP_571835
319
36295
Y152
W
R
H
F
G
A
E
Y
K
D
M
H
T
D
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O76511
321
36638
Y152
W
R
H
F
G
A
Q
Y
G
T
C
D
D
D
Y
Honey Bee
Apis mellifera
XP_624369
305
35528
Y138
W
R
H
F
G
A
T
Y
K
D
M
Y
K
D
Y
Nematode Worm
Caenorhab. elegans
NP_491532
312
35434
Y145
W
R
H
F
G
A
K
Y
V
D
C
H
T
D
Y
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O81395
521
58947
Y354
W
R
H
F
G
A
E
Y
T
D
M
H
A
D
Y
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q05763
565
63190
Y398
W
R
H
F
G
A
K
Y
T
D
M
H
A
D
Y
Baker's Yeast
Sacchar. cerevisiae
P06785
304
35029
Y128
W
R
H
F
G
A
K
Y
K
T
C
D
D
D
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
97.7
84.6
N.A.
88.8
88.5
N.A.
82.4
81.1
79.5
74.9
N.A.
62.9
65.5
62.6
N.A.
Protein Similarity:
100
100
99
89.5
N.A.
93.6
93.2
N.A.
91
87.8
87.5
84.9
N.A.
76
77.9
73.8
N.A.
P-Site Identity:
100
100
100
80
N.A.
86.6
80
N.A.
73.3
73.3
73.3
80
N.A.
60
73.3
66.6
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
93.3
93.3
86.6
93.3
N.A.
73.3
80
80
N.A.
Percent
Protein Identity:
N.A.
39.7
N.A.
37.1
60
N.A.
Protein Similarity:
N.A.
48.1
N.A.
44.4
73.8
N.A.
P-Site Identity:
N.A.
80
N.A.
73.3
60
N.A.
P-Site Similarity:
N.A.
86.6
N.A.
86.6
80
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
100
0
0
0
0
0
0
13
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
19
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
13
0
0
82
0
32
13
100
0
% D
% Glu:
0
0
0
0
0
0
57
0
0
7
0
19
0
0
0
% E
% Phe:
0
0
0
100
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
100
0
0
0
7
0
0
0
0
0
0
% G
% His:
0
0
100
0
0
0
0
0
0
0
0
38
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
19
0
57
0
7
0
7
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
69
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% Q
% Arg:
0
100
0
0
0
0
0
0
19
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
38
0
0
% S
% Thr:
0
0
0
0
0
0
7
0
13
13
7
0
32
0
0
% T
% Val:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% V
% Trp:
100
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
100
0
0
0
7
0
0
100
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _