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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TYMS
All Species:
55.15
Human Site:
Y301
Identified Species:
80.89
UniProt:
P04818
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P04818
NP_001062.1
313
35716
Y301
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
Chimpanzee
Pan troglodytes
XP_001150437
313
35656
Y301
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
Rhesus Macaque
Macaca mulatta
XP_001089274
313
35614
Y301
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
Dog
Lupus familis
XP_533309
325
36767
S302
E
D
F
Q
I
E
G
S
A
N
F
K
N
Y
T
Cat
Felis silvestris
Mouse
Mus musculus
P07607
307
34940
Y295
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
Rat
Rattus norvegicus
P45352
307
34999
Y295
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508361
313
35234
Y301
E
D
F
Q
I
E
D
Y
N
P
H
P
A
I
K
Chicken
Gallus gallus
XP_419147
298
34062
Y286
E
D
F
Q
I
E
D
Y
N
P
H
P
P
I
K
Frog
Xenopus laevis
NP_001096659
309
35145
Y297
D
D
F
L
I
E
G
Y
D
P
H
P
P
I
K
Zebra Danio
Brachydanio rerio
NP_571835
319
36295
Y307
E
D
F
E
I
Y
D
Y
D
P
H
P
T
I
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O76511
321
36638
Y309
E
D
F
Q
I
V
D
Y
N
P
H
P
K
I
Q
Honey Bee
Apis mellifera
XP_624369
305
35528
Y293
N
D
F
E
L
I
G
Y
D
P
H
A
K
I
S
Nematode Worm
Caenorhab. elegans
NP_491532
312
35434
Y300
D
M
I
A
L
D
D
Y
K
C
H
P
K
I
P
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O81395
521
58947
Y509
S
D
F
K
L
V
G
Y
D
P
H
Q
K
I
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q05763
565
63190
Y553
D
D
F
E
L
I
G
Y
D
P
H
K
K
I
D
Baker's Yeast
Sacchar. cerevisiae
P06785
304
35029
Y292
T
D
F
E
I
E
D
Y
N
P
H
P
R
I
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
97.7
84.6
N.A.
88.8
88.5
N.A.
82.4
81.1
79.5
74.9
N.A.
62.9
65.5
62.6
N.A.
Protein Similarity:
100
100
99
89.5
N.A.
93.6
93.2
N.A.
91
87.8
87.5
84.9
N.A.
76
77.9
73.8
N.A.
P-Site Identity:
100
100
100
46.6
N.A.
100
100
N.A.
86.6
86.6
73.3
73.3
N.A.
73.3
46.6
26.6
N.A.
P-Site Similarity:
100
100
100
46.6
N.A.
100
100
N.A.
86.6
86.6
86.6
86.6
N.A.
80
66.6
46.6
N.A.
Percent
Protein Identity:
N.A.
39.7
N.A.
37.1
60
N.A.
Protein Similarity:
N.A.
48.1
N.A.
44.4
73.8
N.A.
P-Site Identity:
N.A.
46.6
N.A.
46.6
66.6
N.A.
P-Site Similarity:
N.A.
73.3
N.A.
73.3
80
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
0
0
0
0
7
0
0
7
7
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% C
% Asp:
19
94
0
0
0
7
38
0
32
0
0
0
0
0
7
% D
% Glu:
63
0
0
25
0
63
0
0
0
0
0
0
0
0
7
% E
% Phe:
0
0
94
0
0
0
0
0
0
0
7
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
63
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
94
0
0
0
0
% H
% Ile:
0
0
7
0
75
13
0
0
0
0
0
0
0
94
0
% I
% Lys:
0
0
0
7
0
0
0
0
7
0
0
13
32
0
57
% K
% Leu:
0
0
0
7
25
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
0
0
0
0
0
0
57
7
0
0
7
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
88
0
75
13
0
7
% P
% Gln:
0
0
0
57
0
0
0
0
0
0
0
7
0
0
13
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% R
% Ser:
7
0
0
0
0
0
0
7
0
0
0
0
0
0
7
% S
% Thr:
7
0
0
0
0
0
0
0
0
0
0
0
38
0
7
% T
% Val:
0
0
0
0
0
13
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
7
0
94
0
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _