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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RPN2
All Species:
27.58
Human Site:
S250
Identified Species:
55.15
UniProt:
P04844
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P04844
NP_001129243.1
631
69284
S250
K
K
N
F
E
S
L
S
E
A
F
S
V
A
S
Chimpanzee
Pan troglodytes
XP_514629
576
63564
S212
V
V
P
E
G
S
A
S
D
T
H
E
Q
A
I
Rhesus Macaque
Macaca mulatta
XP_001097464
601
65921
Q237
I
K
E
D
Q
V
I
Q
L
M
N
A
I
F
S
Dog
Lupus familis
XP_865679
631
69015
S250
K
K
N
F
E
S
L
S
E
A
F
S
V
A
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9DBG6
631
69044
S250
K
K
N
F
E
S
L
S
E
A
F
S
V
A
S
Rat
Rattus norvegicus
P25235
631
69059
S250
K
K
N
F
E
S
L
S
E
A
F
S
V
A
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001006288
631
68881
S251
K
K
N
F
E
T
L
S
E
A
F
S
V
A
C
Frog
Xenopus laevis
NP_001079661
631
69212
S250
R
K
N
F
D
S
I
S
E
A
F
S
V
A
L
Zebra Danio
Brachydanio rerio
NP_997913
630
68922
S248
K
K
S
W
D
S
L
S
E
A
F
S
V
V
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_611265
634
69211
K253
R
R
S
V
Q
T
A
K
G
A
H
V
L
I
E
Honey Bee
Apis mellifera
XP_395511
673
75606
R280
R
R
S
V
Q
T
P
R
G
V
T
S
L
L
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783899
827
89264
R247
R
Q
S
T
Q
S
V
R
N
A
Y
F
V
L
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88.5
94.1
95.8
N.A.
92.3
93.8
N.A.
N.A.
78.1
73.2
66.7
N.A.
33.7
32.6
N.A.
33.3
Protein Similarity:
100
88.9
94.6
98
N.A.
95.4
96
N.A.
N.A.
90.3
86.5
82.7
N.A.
52.2
52
N.A.
49.9
P-Site Identity:
100
20
13.3
100
N.A.
100
100
N.A.
N.A.
86.6
73.3
73.3
N.A.
6.6
13.3
N.A.
26.6
P-Site Similarity:
100
26.6
40
100
N.A.
100
100
N.A.
N.A.
93.3
93.3
93.3
N.A.
46.6
53.3
N.A.
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
17
0
0
75
0
9
0
59
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% C
% Asp:
0
0
0
9
17
0
0
0
9
0
0
0
0
0
0
% D
% Glu:
0
0
9
9
42
0
0
0
59
0
0
9
0
0
9
% E
% Phe:
0
0
0
50
0
0
0
0
0
0
59
9
0
9
0
% F
% Gly:
0
0
0
0
9
0
0
0
17
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
17
0
0
0
0
% H
% Ile:
9
0
0
0
0
0
17
0
0
0
0
0
9
9
9
% I
% Lys:
50
67
0
0
0
0
0
9
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
50
0
9
0
0
0
17
17
9
% L
% Met:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% M
% Asn:
0
0
50
0
0
0
0
0
9
0
9
0
0
0
0
% N
% Pro:
0
0
9
0
0
0
9
0
0
0
0
0
0
0
0
% P
% Gln:
0
9
0
0
34
0
0
9
0
0
0
0
9
0
0
% Q
% Arg:
34
17
0
0
0
0
0
17
0
0
0
0
0
0
0
% R
% Ser:
0
0
34
0
0
67
0
67
0
0
0
67
0
0
67
% S
% Thr:
0
0
0
9
0
25
0
0
0
9
9
0
0
0
0
% T
% Val:
9
9
0
17
0
9
9
0
0
9
0
9
67
9
0
% V
% Trp:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _