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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IGF1
All Species:
12.12
Human Site:
Y135
Identified Species:
29.63
UniProt:
P05019
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P05019
NP_001104755.1
195
21841
Y135
D
M
P
K
T
Q
K
Y
Q
P
P
S
T
N
K
Chimpanzee
Pan troglodytes
XP_001156459
196
21850
Y135
D
M
P
K
T
Q
K
Y
Q
P
P
S
T
N
K
Rhesus Macaque
Macaca mulatta
XP_001093911
208
23233
Y135
D
M
P
K
T
Q
K
Y
Q
P
P
S
T
N
K
Dog
Lupus familis
XP_866946
159
17858
R104
F
R
S
C
D
L
R
R
L
E
M
Y
C
A
P
Cat
Felis silvestris
Mouse
Mus musculus
P05017
153
17075
R98
I
V
D
E
C
C
F
R
S
C
D
L
R
R
L
Rat
Rattus norvegicus
P08025
153
17060
R98
I
V
D
E
C
C
F
R
S
C
D
L
R
R
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507349
242
27362
Y135
D
M
P
K
A
Q
K
Y
Q
P
A
I
S
P
S
Chicken
Gallus gallus
P18254
153
17249
Q98
I
V
D
E
C
C
F
Q
S
C
D
L
R
R
L
Frog
Xenopus laevis
P16501
153
17392
Q98
I
V
D
E
C
C
F
Q
S
C
D
F
R
R
L
Zebra Danio
Brachydanio rerio
NP_571900
161
17907
A106
R
R
L
E
M
Y
C
A
P
V
K
T
G
K
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
93.2
75.9
N.A.
68.2
69.2
N.A.
64.8
63.5
58.4
50.2
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
98.9
93.2
76.9
N.A.
71.2
71.7
N.A.
69.4
67.1
63
60.5
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
0
N.A.
0
0
N.A.
60
0
0
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
6.6
N.A.
13.3
13.3
N.A.
66.6
13.3
13.3
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
10
0
0
10
0
0
10
0
0
10
0
% A
% Cys:
0
0
0
10
40
40
10
0
0
40
0
0
10
0
0
% C
% Asp:
40
0
40
0
10
0
0
0
0
0
40
0
0
0
0
% D
% Glu:
0
0
0
50
0
0
0
0
0
10
0
0
0
0
0
% E
% Phe:
10
0
0
0
0
0
40
0
0
0
0
10
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
40
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% I
% Lys:
0
0
0
40
0
0
40
0
0
0
10
0
0
10
30
% K
% Leu:
0
0
10
0
0
10
0
0
10
0
0
30
0
0
40
% L
% Met:
0
40
0
0
10
0
0
0
0
0
10
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
30
0
% N
% Pro:
0
0
40
0
0
0
0
0
10
40
30
0
0
10
10
% P
% Gln:
0
0
0
0
0
40
0
20
40
0
0
0
0
0
0
% Q
% Arg:
10
20
0
0
0
0
10
30
0
0
0
0
40
40
0
% R
% Ser:
0
0
10
0
0
0
0
0
40
0
0
30
10
0
20
% S
% Thr:
0
0
0
0
30
0
0
0
0
0
0
10
30
0
0
% T
% Val:
0
40
0
0
0
0
0
0
0
10
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
10
0
40
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _