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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ALDH2 All Species: 45.15
Human Site: T124 Identified Species: 76.41
UniProt: P05091 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P05091 NP_000681.2 517 56381 T124 T Y L A A L E T L D N G K P Y
Chimpanzee Pan troglodytes XP_509379 517 55884 T124 E G D K A L E T L D N G K P Y
Rhesus Macaque Macaca mulatta XP_001114412 517 57157 T124 V Y L A S L E T L D N G K P F
Dog Lupus familis XP_853628 521 56744 T128 T Y L A A L E T L D N G K P Y
Cat Felis silvestris
Mouse Mus musculus P47738 519 56519 T126 T Y L A A L E T L D N G K P Y
Rat Rattus norvegicus P11884 519 56470 T126 T Y L A A L E T L D N G K P Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506461 571 62215 T178 T Y L A T L E T L D N G K P Y
Chicken Gallus gallus P27463 509 55791 A116 L T L A T M E A I D G G K L F
Frog Xenopus laevis NP_001087022 521 57231 T128 A I L A T L E T L D N G K P Y
Zebra Danio Brachydanio rerio NP_956784 516 56547 T123 A Y L A E L E T L D N G K P Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609285 520 57001 T127 V Y L A S L E T L D N G K P Y
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786787 525 56894 T132 A H L A S L E T L D N G K P Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SU63 538 58570 T144 E E L A S L E T W D N G K P Y
Baker's Yeast Sacchar. cerevisiae P32872 511 56448 H129 D I L A A I E H L D N G K P F
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 79.6 72.5 93.6 N.A. 94.9 95.5 N.A. 79.8 66.5 79.4 78.3 N.A. 69.4 N.A. N.A. 66.6
Protein Similarity: 100 83.7 84.3 97.3 N.A. 97.1 97.6 N.A. 84.7 79.8 88.6 88.9 N.A. 81.1 N.A. N.A. 81.5
P-Site Identity: 100 73.3 80 100 N.A. 100 100 N.A. 93.3 40 80 86.6 N.A. 86.6 N.A. N.A. 80
P-Site Similarity: 100 73.3 93.3 100 N.A. 100 100 N.A. 93.3 60 80 86.6 N.A. 93.3 N.A. N.A. 93.3
Percent
Protein Identity: N.A. N.A. N.A. 58.3 56.8 N.A.
Protein Similarity: N.A. N.A. N.A. 70.4 67.7 N.A.
P-Site Identity: N.A. N.A. N.A. 73.3 66.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 80 80 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 22 0 0 93 43 0 0 8 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 8 0 0 0 0 0 0 100 0 0 0 0 0 % D
% Glu: 15 8 0 0 8 0 100 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 22 % F
% Gly: 0 8 0 0 0 0 0 0 0 0 8 100 0 0 0 % G
% His: 0 8 0 0 0 0 0 8 0 0 0 0 0 0 0 % H
% Ile: 0 15 0 0 0 8 0 0 8 0 0 0 0 0 0 % I
% Lys: 0 0 0 8 0 0 0 0 0 0 0 0 100 0 0 % K
% Leu: 8 0 93 0 0 86 0 0 86 0 0 0 0 8 0 % L
% Met: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 93 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 93 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 29 0 0 0 0 0 0 0 0 0 0 % S
% Thr: 36 8 0 0 22 0 0 86 0 0 0 0 0 0 0 % T
% Val: 15 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % W
% Tyr: 0 58 0 0 0 0 0 0 0 0 0 0 0 0 79 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _