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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ALDH2
All Species:
40
Human Site:
T376
Identified Species:
67.69
UniProt:
P05091
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P05091
NP_000681.2
517
56381
T376
K
I
L
G
Y
I
N
T
G
K
Q
E
G
A
K
Chimpanzee
Pan troglodytes
XP_509379
517
55884
T376
K
I
L
G
Y
I
N
T
G
K
Q
E
G
A
K
Rhesus Macaque
Macaca mulatta
XP_001114412
517
57157
L376
R
V
L
G
Y
I
Q
L
G
Q
K
E
G
A
K
Dog
Lupus familis
XP_853628
521
56744
S380
K
I
L
G
Y
I
K
S
G
K
E
E
G
A
K
Cat
Felis silvestris
Mouse
Mus musculus
P47738
519
56519
S378
K
I
L
G
Y
I
K
S
G
Q
Q
E
G
A
K
Rat
Rattus norvegicus
P11884
519
56470
S378
K
I
L
G
Y
I
K
S
G
Q
Q
E
G
A
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506461
571
62215
A430
K
I
L
G
Y
I
S
A
G
K
R
E
G
A
K
Chicken
Gallus gallus
P27463
509
55791
S368
K
I
L
D
L
I
E
S
G
K
K
E
G
A
K
Frog
Xenopus laevis
NP_001087022
521
57231
S380
K
I
L
G
Y
I
K
S
G
K
K
E
G
A
K
Zebra Danio
Brachydanio rerio
NP_956784
516
56547
S375
K
V
L
G
Y
I
S
S
G
K
R
E
G
A
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609285
520
57001
T378
K
I
L
G
M
I
K
T
G
K
K
Q
G
A
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786787
525
56894
S384
K
I
L
G
L
I
E
S
G
K
S
D
G
A
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SU63
538
58570
S396
K
V
M
K
Y
I
K
S
G
I
E
S
N
A
T
Baker's Yeast
Sacchar. cerevisiae
P32872
511
56448
I377
Y
G
P
Q
I
L
K
I
E
F
D
S
I
P
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
79.6
72.5
93.6
N.A.
94.9
95.5
N.A.
79.8
66.5
79.4
78.3
N.A.
69.4
N.A.
N.A.
66.6
Protein Similarity:
100
83.7
84.3
97.3
N.A.
97.1
97.6
N.A.
84.7
79.8
88.6
88.9
N.A.
81.1
N.A.
N.A.
81.5
P-Site Identity:
100
100
60
80
N.A.
80
80
N.A.
80
66.6
80
73.3
N.A.
73.3
N.A.
N.A.
66.6
P-Site Similarity:
100
100
86.6
93.3
N.A.
93.3
93.3
N.A.
93.3
80
93.3
100
N.A.
86.6
N.A.
N.A.
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
58.3
56.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
70.4
67.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
33.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
8
0
0
0
0
0
93
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
0
0
0
0
8
8
0
0
0
% D
% Glu:
0
0
0
0
0
0
15
0
8
0
15
72
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
8
0
79
0
0
0
0
93
0
0
0
86
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
72
0
0
8
93
0
8
0
8
0
0
8
0
0
% I
% Lys:
86
0
0
8
0
0
50
0
0
65
29
0
0
0
86
% K
% Leu:
0
0
86
0
15
8
0
8
0
0
0
0
0
0
0
% L
% Met:
0
0
8
0
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
15
0
0
0
0
0
8
0
0
% N
% Pro:
0
0
8
0
0
0
0
0
0
0
0
0
0
8
0
% P
% Gln:
0
0
0
8
0
0
8
0
0
22
29
8
0
0
0
% Q
% Arg:
8
0
0
0
0
0
0
0
0
0
15
0
0
0
8
% R
% Ser:
0
0
0
0
0
0
15
58
0
0
8
15
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
22
0
0
0
0
0
0
8
% T
% Val:
0
22
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
72
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _