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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ALDH2
All Species:
41.82
Human Site:
Y135
Identified Species:
70.77
UniProt:
P05091
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P05091
NP_000681.2
517
56381
Y135
G
K
P
Y
V
I
S
Y
L
V
D
L
D
M
V
Chimpanzee
Pan troglodytes
XP_509379
517
55884
Y135
G
K
P
Y
V
I
S
Y
L
V
D
L
D
M
V
Rhesus Macaque
Macaca mulatta
XP_001114412
517
57157
Y135
G
K
P
F
Q
E
S
Y
A
L
D
L
D
E
V
Dog
Lupus familis
XP_853628
521
56744
Y139
G
K
P
Y
V
I
S
Y
L
V
D
L
D
M
V
Cat
Felis silvestris
Mouse
Mus musculus
P47738
519
56519
Y137
G
K
P
Y
V
I
S
Y
L
V
D
L
D
M
V
Rat
Rattus norvegicus
P11884
519
56470
Y137
G
K
P
Y
V
I
S
Y
L
V
D
L
D
M
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506461
571
62215
Y189
G
K
P
Y
S
I
S
Y
L
V
D
L
D
M
V
Chicken
Gallus gallus
P27463
509
55791
Y127
G
K
L
F
S
T
A
Y
L
M
D
L
G
A
C
Frog
Xenopus laevis
NP_001087022
521
57231
Y139
G
K
P
Y
A
I
S
Y
A
V
D
L
D
L
V
Zebra Danio
Brachydanio rerio
NP_956784
516
56547
F134
G
K
P
Y
T
L
S
F
C
V
D
L
P
M
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609285
520
57001
Y138
G
K
P
Y
S
M
S
Y
N
V
D
L
P
T
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786787
525
56894
Y143
G
K
P
Y
Q
D
S
Y
T
I
D
V
P
G
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SU63
538
58570
L155
G
K
P
Y
Q
Q
S
L
T
A
E
I
P
M
F
Baker's Yeast
Sacchar. cerevisiae
P32872
511
56448
Y140
G
K
P
F
D
E
A
Y
L
L
D
L
A
S
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
79.6
72.5
93.6
N.A.
94.9
95.5
N.A.
79.8
66.5
79.4
78.3
N.A.
69.4
N.A.
N.A.
66.6
Protein Similarity:
100
83.7
84.3
97.3
N.A.
97.1
97.6
N.A.
84.7
79.8
88.6
88.9
N.A.
81.1
N.A.
N.A.
81.5
P-Site Identity:
100
100
60
100
N.A.
100
100
N.A.
93.3
40
80
66.6
N.A.
60
N.A.
N.A.
53.3
P-Site Similarity:
100
100
73.3
100
N.A.
100
100
N.A.
93.3
60
86.6
80
N.A.
66.6
N.A.
N.A.
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
58.3
56.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
70.4
67.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
53.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
15
0
15
8
0
0
8
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
8
% C
% Asp:
0
0
0
0
8
8
0
0
0
0
93
0
58
0
0
% D
% Glu:
0
0
0
0
0
15
0
0
0
0
8
0
0
8
0
% E
% Phe:
0
0
0
22
0
0
0
8
0
0
0
0
0
0
8
% F
% Gly:
100
0
0
0
0
0
0
0
0
0
0
0
8
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
50
0
0
0
8
0
8
0
0
0
% I
% Lys:
0
100
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
8
0
0
8
0
8
58
15
0
86
0
8
0
% L
% Met:
0
0
0
0
0
8
0
0
0
8
0
0
0
58
0
% M
% Asn:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% N
% Pro:
0
0
93
0
0
0
0
0
0
0
0
0
29
0
0
% P
% Gln:
0
0
0
0
22
8
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
22
0
86
0
0
0
0
0
0
8
0
% S
% Thr:
0
0
0
0
8
8
0
0
15
0
0
0
0
8
0
% T
% Val:
0
0
0
0
36
0
0
0
0
65
0
8
0
0
79
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
79
0
0
0
86
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _