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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ALDH2
All Species:
45.15
Human Site:
Y458
Identified Species:
76.41
UniProt:
P05091
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P05091
NP_000681.2
517
56381
Y458
K
D
L
D
K
A
N
Y
L
S
Q
A
L
Q
A
Chimpanzee
Pan troglodytes
XP_509379
517
55884
Y458
K
D
L
D
K
A
N
Y
L
S
Q
A
L
Q
A
Rhesus Macaque
Macaca mulatta
XP_001114412
517
57157
Y458
R
D
L
D
K
A
M
Y
F
T
Q
A
L
Q
A
Dog
Lupus familis
XP_853628
521
56744
Y462
K
D
L
D
K
A
N
Y
L
S
Q
A
L
Q
A
Cat
Felis silvestris
Mouse
Mus musculus
P47738
519
56519
Y460
K
D
L
D
K
A
N
Y
L
S
Q
A
L
Q
A
Rat
Rattus norvegicus
P11884
519
56470
Y460
K
D
L
D
K
A
N
Y
L
S
Q
A
L
Q
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506461
571
62215
Y512
K
D
L
D
K
A
N
Y
I
S
Q
V
L
Q
A
Chicken
Gallus gallus
P27463
509
55791
T450
K
D
I
D
K
A
L
T
F
A
S
A
L
Q
A
Frog
Xenopus laevis
NP_001087022
521
57231
T462
K
D
I
D
K
A
H
T
F
S
Q
S
V
R
A
Zebra Danio
Brachydanio rerio
NP_956784
516
56547
Y457
Q
N
I
D
K
A
N
Y
I
S
H
G
L
R
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609285
520
57001
Y461
K
D
L
D
K
A
N
Y
I
V
G
G
L
R
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786787
525
56894
Y466
K
D
I
D
K
A
L
Y
V
S
N
S
L
R
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SU63
538
58570
R478
K
N
L
D
T
A
N
R
V
S
R
A
L
K
A
Baker's Yeast
Sacchar. cerevisiae
P32872
511
56448
D451
D
E
A
I
K
R
V
D
N
T
K
Y
G
L
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
79.6
72.5
93.6
N.A.
94.9
95.5
N.A.
79.8
66.5
79.4
78.3
N.A.
69.4
N.A.
N.A.
66.6
Protein Similarity:
100
83.7
84.3
97.3
N.A.
97.1
97.6
N.A.
84.7
79.8
88.6
88.9
N.A.
81.1
N.A.
N.A.
81.5
P-Site Identity:
100
100
73.3
100
N.A.
100
100
N.A.
86.6
60
53.3
53.3
N.A.
66.6
N.A.
N.A.
60
P-Site Similarity:
100
100
86.6
100
N.A.
100
100
N.A.
93.3
73.3
86.6
86.6
N.A.
80
N.A.
N.A.
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
58.3
56.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
70.4
67.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
60
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
86.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
93
0
0
0
8
0
58
0
0
100
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
79
0
93
0
0
0
8
0
0
0
0
0
0
0
% D
% Glu:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
22
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
8
15
8
0
0
% G
% His:
0
0
0
0
0
0
8
0
0
0
8
0
0
0
0
% H
% Ile:
0
0
29
8
0
0
0
0
22
0
0
0
0
0
0
% I
% Lys:
79
0
0
0
93
0
0
0
0
0
8
0
0
8
0
% K
% Leu:
0
0
65
0
0
0
15
0
36
0
0
0
86
8
0
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
15
0
0
0
0
65
0
8
0
8
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
8
0
0
0
0
0
0
0
0
0
58
0
0
58
0
% Q
% Arg:
8
0
0
0
0
8
0
8
0
0
8
0
0
29
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
72
8
15
0
0
0
% S
% Thr:
0
0
0
0
8
0
0
15
0
15
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
8
0
15
8
0
8
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
72
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _