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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP17A1
All Species:
23.94
Human Site:
S258
Identified Species:
52.67
UniProt:
P05093
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P05093
NP_000093.1
508
57371
S258
K
E
K
F
R
S
D
S
I
T
N
M
L
D
T
Chimpanzee
Pan troglodytes
Q8HYN1
508
57365
S258
K
E
K
F
R
S
D
S
I
T
N
M
L
D
T
Rhesus Macaque
Macaca mulatta
Q8HYM9
508
57600
S258
K
E
K
F
H
S
D
S
I
T
N
M
L
D
V
Dog
Lupus familis
XP_851226
511
57803
S258
K
E
K
F
S
S
D
S
I
T
N
M
L
D
I
Cat
Felis silvestris
Mouse
Mus musculus
P27786
507
57619
S257
K
E
K
F
N
S
E
S
L
S
S
L
T
D
I
Rat
Rattus norvegicus
P11715
507
57232
S257
R
E
K
F
D
S
Q
S
I
S
S
L
T
D
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P12394
508
56966
T263
K
E
A
F
C
G
D
T
V
R
D
L
M
D
A
Frog
Xenopus laevis
NP_001090540
511
57749
E263
H
K
E
A
F
C
N
E
E
V
N
D
L
L
D
Zebra Danio
Brachydanio rerio
NP_997971
519
58317
V271
K
V
T
Y
S
D
N
V
Q
R
D
L
L
D
A
Tiger Blowfish
Takifugu rubipres
NP_001098706
517
57319
Q267
A
A
Y
S
D
H
V
Q
R
D
L
L
D
A
L
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_789963
507
57031
Y266
V
D
E
A
R
E
H
Y
D
P
E
N
I
N
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
94.4
78.4
N.A.
66.7
68.3
N.A.
N.A.
48.4
48.9
48.9
48.1
N.A.
N.A.
N.A.
31.8
Protein Similarity:
100
100
96.6
90
N.A.
81.3
82
N.A.
N.A.
69.2
67.3
66.4
64.9
N.A.
N.A.
N.A.
52.5
P-Site Identity:
100
100
86.6
86.6
N.A.
46.6
46.6
N.A.
N.A.
33.3
13.3
20
0
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
86.6
86.6
N.A.
80
73.3
N.A.
N.A.
66.6
33.3
46.6
6.6
N.A.
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
10
19
0
0
0
0
0
0
0
0
0
10
19
% A
% Cys:
0
0
0
0
10
10
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
19
10
46
0
10
10
19
10
10
73
19
% D
% Glu:
0
64
19
0
0
10
10
10
10
0
10
0
0
0
0
% E
% Phe:
0
0
0
64
10
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% G
% His:
10
0
0
0
10
10
10
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
46
0
0
0
10
0
28
% I
% Lys:
64
10
55
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
10
0
10
46
55
10
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
37
10
0
0
% M
% Asn:
0
0
0
0
10
0
19
0
0
0
46
10
0
10
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
10
10
10
0
0
0
0
0
0
% Q
% Arg:
10
0
0
0
28
0
0
0
10
19
0
0
0
0
0
% R
% Ser:
0
0
0
10
19
55
0
55
0
19
19
0
0
0
0
% S
% Thr:
0
0
10
0
0
0
0
10
0
37
0
0
19
0
19
% T
% Val:
10
10
0
0
0
0
10
10
10
10
0
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
10
10
0
0
0
10
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _