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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SERPINE1
All Species:
24.85
Human Site:
S333
Identified Species:
60.74
UniProt:
P05121
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P05121
NP_000593.1
402
45060
S333
Q
A
D
F
T
S
L
S
D
Q
E
P
L
H
V
Chimpanzee
Pan troglodytes
XP_527841
701
77863
S632
R
A
D
F
T
S
L
S
D
Q
E
P
L
H
V
Rhesus Macaque
Macaca mulatta
XP_001107647
402
45064
S333
Q
A
D
F
T
S
L
S
N
Q
E
P
L
H
V
Dog
Lupus familis
XP_849345
402
45274
S333
L
A
D
F
S
S
L
S
N
Q
E
V
L
Y
V
Cat
Felis silvestris
Mouse
Mus musculus
P22777
402
45152
S333
L
A
D
F
T
S
L
S
D
Q
E
Q
L
S
V
Rat
Rattus norvegicus
P20961
402
44991
S333
Q
A
D
F
T
S
L
S
D
Q
E
Q
L
S
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519685
168
18816
E116
A
L
Q
K
A
K
I
E
V
N
E
S
G
T
V
Chicken
Gallus gallus
Q90935
410
46511
M325
R
S
A
D
L
T
A
M
S
D
N
K
E
L
Y
Frog
Xenopus laevis
Q52L45
377
42679
S315
G
S
N
N
L
F
L
S
E
V
I
H
K
S
F
Zebra Danio
Brachydanio rerio
B0UYL8
417
46382
S344
A
A
D
F
R
G
I
S
D
T
D
G
I
F
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
57.2
97.2
86
N.A.
78.6
80.8
N.A.
32.3
33.6
30.8
30.2
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
57.3
98.7
92
N.A.
88.8
89.8
N.A.
37
55.3
46.5
53
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
93.3
93.3
66.6
N.A.
80
86.6
N.A.
13.3
0
13.3
40
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
86.6
N.A.
80
86.6
N.A.
20
20
33.3
60
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
70
10
0
10
0
10
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
70
10
0
0
0
0
50
10
10
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
10
10
0
70
0
10
0
0
% E
% Phe:
0
0
0
70
0
10
0
0
0
0
0
0
0
10
10
% F
% Gly:
10
0
0
0
0
10
0
0
0
0
0
10
10
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
10
0
30
0
% H
% Ile:
0
0
0
0
0
0
20
0
0
0
10
0
10
0
0
% I
% Lys:
0
0
0
10
0
10
0
0
0
0
0
10
10
0
0
% K
% Leu:
20
10
0
0
20
0
70
0
0
0
0
0
60
10
0
% L
% Met:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
10
0
0
0
0
20
10
10
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
30
0
0
0
% P
% Gln:
30
0
10
0
0
0
0
0
0
60
0
20
0
0
0
% Q
% Arg:
20
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
20
0
0
10
60
0
80
10
0
0
10
0
30
0
% S
% Thr:
0
0
0
0
50
10
0
0
0
10
0
0
0
10
0
% T
% Val:
0
0
0
0
0
0
0
0
10
10
0
10
0
0
80
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _