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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SERPINE1
All Species:
25.15
Human Site:
S354
Identified Species:
61.48
UniProt:
P05121
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P05121
NP_000593.1
402
45060
S354
V
K
I
E
V
N
E
S
G
T
V
A
S
S
S
Chimpanzee
Pan troglodytes
XP_527841
701
77863
S653
V
K
I
E
V
N
E
S
G
T
V
A
S
S
S
Rhesus Macaque
Macaca mulatta
XP_001107647
402
45064
S354
V
K
I
E
V
N
E
S
G
T
V
A
S
S
S
Dog
Lupus familis
XP_849345
402
45274
S354
V
K
I
E
V
N
E
S
G
T
V
A
S
S
S
Cat
Felis silvestris
Mouse
Mus musculus
P22777
402
45152
S354
V
R
I
E
V
N
E
S
G
T
V
A
S
S
S
Rat
Rattus norvegicus
P20961
402
44991
S354
V
K
I
E
V
N
E
S
G
T
V
A
S
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519685
168
18816
R131
A
S
A
A
T
A
I
R
I
S
A
R
M
V
P
Chicken
Gallus gallus
Q90935
410
46511
E347
A
F
L
E
V
N
E
E
G
S
E
A
A
A
A
Frog
Xenopus laevis
Q52L45
377
42679
T330
V
E
V
N
E
E
G
T
E
A
A
A
A
S
A
Zebra Danio
Brachydanio rerio
B0UYL8
417
46382
A365
A
R
I
E
V
T
E
A
G
T
K
A
A
S
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
57.2
97.2
86
N.A.
78.6
80.8
N.A.
32.3
33.6
30.8
30.2
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
57.3
98.7
92
N.A.
88.8
89.8
N.A.
37
55.3
46.5
53
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
93.3
100
N.A.
0
40
20
53.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
6.6
73.3
53.3
80
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
30
0
10
10
0
10
0
10
0
10
20
90
30
10
30
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
10
0
80
10
10
80
10
10
0
10
0
0
0
0
% E
% Phe:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
10
0
80
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
70
0
0
0
10
0
10
0
0
0
0
0
0
% I
% Lys:
0
50
0
0
0
0
0
0
0
0
10
0
0
0
0
% K
% Leu:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% M
% Asn:
0
0
0
10
0
70
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
20
0
0
0
0
0
10
0
0
0
10
0
0
0
% R
% Ser:
0
10
0
0
0
0
0
60
0
20
0
0
60
80
60
% S
% Thr:
0
0
0
0
10
10
0
10
0
70
0
0
0
0
0
% T
% Val:
70
0
10
0
80
0
0
0
0
0
60
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _