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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ISG15
All Species:
13.33
Human Site:
T125
Identified Species:
32.59
UniProt:
P05161
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P05161
NP_005092.1
165
17888
T125
Q
D
D
L
F
W
L
T
F
E
G
K
P
L
E
Chimpanzee
Pan troglodytes
XP_520842
165
17824
T125
Q
D
D
L
F
W
L
T
F
E
G
K
P
L
E
Rhesus Macaque
Macaca mulatta
XP_001088541
165
17996
T125
Q
D
D
L
F
W
L
T
F
E
G
K
P
L
E
Dog
Lupus familis
XP_536714
174
18986
T131
Q
A
D
L
F
W
L
T
F
E
G
K
P
M
E
Cat
Felis silvestris
Mouse
Mus musculus
Q64339
161
17879
W121
Q
V
H
E
D
Q
F
W
L
S
F
E
G
R
P
Rat
Rattus norvegicus
Q05474
74
7723
A35
V
A
S
L
E
G
I
A
P
E
D
Q
V
V
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_687341
157
17670
P118
I
Y
Q
K
E
R
V
P
K
D
Q
Q
R
L
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14792
76
8520
P37
I
Q
D
K
E
G
I
P
P
D
Q
Q
R
L
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P59263
76
8506
P37
I
Q
D
K
E
G
I
P
P
D
Q
Q
R
L
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
P13117
76
8579
P37
I
Q
D
K
E
G
I
P
P
D
Q
Q
R
L
I
Conservation
Percent
Protein Identity:
100
98.1
90.9
66
N.A.
63
20.6
N.A.
N.A.
N.A.
N.A.
33.9
N.A.
N.A.
N.A.
20
N.A.
Protein Similarity:
100
99.3
95.1
70.6
N.A.
75.7
30.2
N.A.
N.A.
N.A.
N.A.
52.7
N.A.
N.A.
N.A.
30.2
N.A.
P-Site Identity:
100
100
100
86.6
N.A.
6.6
13.3
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
13.3
33.3
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20
N.A.
20
Protein Similarity:
N.A.
N.A.
N.A.
29.7
N.A.
31.5
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
20
0
0
0
0
0
10
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
30
70
0
10
0
0
0
0
40
10
0
0
0
0
% D
% Glu:
0
0
0
10
50
0
0
0
0
50
0
10
0
0
40
% E
% Phe:
0
0
0
0
40
0
10
0
40
0
10
0
0
0
0
% F
% Gly:
0
0
0
0
0
40
0
0
0
0
40
0
10
0
0
% G
% His:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
40
0
0
0
0
0
40
0
0
0
0
0
0
0
40
% I
% Lys:
0
0
0
40
0
0
0
0
10
0
0
40
0
0
0
% K
% Leu:
0
0
0
50
0
0
40
0
10
0
0
0
0
70
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
40
40
0
0
0
40
0
10
% P
% Gln:
50
30
10
0
0
10
0
0
0
0
40
50
0
0
0
% Q
% Arg:
0
0
0
0
0
10
0
0
0
0
0
0
40
10
0
% R
% Ser:
0
0
10
0
0
0
0
0
0
10
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
40
0
0
0
0
0
0
0
% T
% Val:
10
10
0
0
0
0
10
0
0
0
0
0
10
10
0
% V
% Trp:
0
0
0
0
0
40
0
10
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _