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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PCCA All Species: 38.48
Human Site: S220 Identified Species: 70.56
UniProt: P05165 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P05165 NP_000273.2 703 77354 S220 T R D G F R L S S Q E A A S S
Chimpanzee Pan troglodytes XP_001149000 728 80070 S245 T R D G F R L S S Q E A A S S
Rhesus Macaque Macaca mulatta XP_001092670 728 79940 S245 T R D G F R L S S Q E A A S S
Dog Lupus familis XP_534175 731 80859 S245 T R D G F R F S S Q E A A S S
Cat Felis silvestris
Mouse Mus musculus Q91ZA3 724 79903 S241 T R D G F R F S S Q E A A S S
Rat Rattus norvegicus P14882 704 77693 S221 T R D G F R F S S Q E A A S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_416970 713 78537 S230 T R E G F R F S S Q E A A S S
Frog Xenopus laevis NP_001089298 710 78429 S227 T R E G F R F S S Q E A A S S
Zebra Danio Brachydanio rerio NP_001002746 709 77797 S226 T R E G F R F S S Q E A A S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q19842 724 79744 S231 A R E G Y R L S K Q E A A S S
Sea Urchin Strong. purpuratus XP_787409 659 72714 H200 K F I D N P R H I E I Q V L A
Poplar Tree Populus trichocarpa B9HBA8 528 57689 C91 A H E M G I P C V A V Y S T I
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q42523 734 80433 A220 F A D S F L G A Q R E A A A S
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.1 94.2 88.5 N.A. 88.2 89.3 N.A. N.A. 81.7 77.7 76 N.A. N.A. N.A. 58 58.4
Protein Similarity: 100 96.4 95.4 93.5 N.A. 92.5 94.3 N.A. N.A. 88.3 86.9 86.7 N.A. N.A. N.A. 74 72.8
P-Site Identity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. N.A. 86.6 86.6 86.6 N.A. N.A. N.A. 73.3 0
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. N.A. 93.3 93.3 93.3 N.A. N.A. N.A. 86.6 13.3
Percent
Protein Identity: 35.9 N.A. N.A. 39.2 N.A. N.A.
Protein Similarity: 50.9 N.A. N.A. 59.1 N.A. N.A.
P-Site Identity: 0 N.A. N.A. 40 N.A. N.A.
P-Site Similarity: 20 N.A. N.A. 60 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 8 0 0 0 0 0 8 0 8 0 85 85 8 8 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % C
% Asp: 0 0 54 8 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 39 0 0 0 0 0 0 8 85 0 0 0 0 % E
% Phe: 8 8 0 0 77 0 47 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 77 8 0 8 0 0 0 0 0 0 0 0 % G
% His: 0 8 0 0 0 0 0 8 0 0 0 0 0 0 0 % H
% Ile: 0 0 8 0 0 8 0 0 8 0 8 0 0 0 8 % I
% Lys: 8 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 8 31 0 0 0 0 0 0 8 0 % L
% Met: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 8 8 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 8 77 0 8 0 0 0 % Q
% Arg: 0 77 0 0 0 77 8 0 0 8 0 0 0 0 0 % R
% Ser: 0 0 0 8 0 0 0 77 70 0 0 0 8 77 85 % S
% Thr: 70 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % T
% Val: 0 0 0 0 0 0 0 0 8 0 8 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 0 0 0 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _