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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PCCA All Species: 44.55
Human Site: S388 Identified Species: 81.67
UniProt: P05165 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P05165 NP_000273.2 703 77354 S388 Y K S F G L P S I G R L S Q Y
Chimpanzee Pan troglodytes XP_001149000 728 80070 S413 Y K S F G L P S I G R L S Q Y
Rhesus Macaque Macaca mulatta XP_001092670 728 79940 S413 Y K S F G L P S I G R L S Q Y
Dog Lupus familis XP_534175 731 80859 S413 Y K S F G L P S I G R L S Q Y
Cat Felis silvestris
Mouse Mus musculus Q91ZA3 724 79903 S409 Y K S F G L P S I G R L S Q Y
Rat Rattus norvegicus P14882 704 77693 S389 Y K S F G L P S I G R L S Q Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_416970 713 78537 S398 Y K S F G L P S I G K L S Q Y
Frog Xenopus laevis NP_001089298 710 78429 S395 Y K S F G L P S I G R L S Q Y
Zebra Danio Brachydanio rerio NP_001002746 709 77797 S394 Y K S F G L P S I G R L S Q Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q19842 724 79744 S399 Y K G F G L P S V G R L S R Y
Sea Urchin Strong. purpuratus XP_787409 659 72714 S344 Y K S F G L P S I G H L H R Y
Poplar Tree Populus trichocarpa B9HBA8 528 57689 G227 I K A T A G G G G R G M R L A
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q42523 734 80433 A388 V P K G F L P A T G V L N H Y
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.1 94.2 88.5 N.A. 88.2 89.3 N.A. N.A. 81.7 77.7 76 N.A. N.A. N.A. 58 58.4
Protein Similarity: 100 96.4 95.4 93.5 N.A. 92.5 94.3 N.A. N.A. 88.3 86.9 86.7 N.A. N.A. N.A. 74 72.8
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. N.A. 93.3 100 100 N.A. N.A. N.A. 80 80
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 100 100 100 N.A. N.A. N.A. 93.3 86.6
Percent
Protein Identity: 35.9 N.A. N.A. 39.2 N.A. N.A.
Protein Similarity: 50.9 N.A. N.A. 59.1 N.A. N.A.
P-Site Identity: 6.6 N.A. N.A. 33.3 N.A. N.A.
P-Site Similarity: 20 N.A. N.A. 46.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 8 0 0 8 0 0 0 0 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 85 8 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 8 8 85 8 8 8 8 93 8 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 8 0 8 8 0 % H
% Ile: 8 0 0 0 0 0 0 0 77 0 0 0 0 0 0 % I
% Lys: 0 93 8 0 0 0 0 0 0 0 8 0 0 0 0 % K
% Leu: 0 0 0 0 0 93 0 0 0 0 0 93 0 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % N
% Pro: 0 8 0 0 0 0 93 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 70 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 8 70 0 8 16 0 % R
% Ser: 0 0 77 0 0 0 0 85 0 0 0 0 77 0 0 % S
% Thr: 0 0 0 8 0 0 0 0 8 0 0 0 0 0 0 % T
% Val: 8 0 0 0 0 0 0 0 8 0 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 85 0 0 0 0 0 0 0 0 0 0 0 0 0 93 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _