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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PCCB All Species: 35.76
Human Site: S233 Identified Species: 65.56
UniProt: P05166 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P05166 NP_000523.2 539 58216 S233 T G P D V V K S V T N E D V T
Chimpanzee Pan troglodytes XP_001150022 595 64057 A260 L L H C S P A A F A I L N G K
Rhesus Macaque Macaca mulatta XP_001114982 539 58170 S233 T G P D V V K S V T N E D V T
Dog Lupus familis XP_534271 554 59958 S248 T G P D V V K S V T N E D V T
Cat Felis silvestris
Mouse Mus musculus Q99MN9 541 58375 S235 T G P E V V K S V T N E D V T
Rat Rattus norvegicus P07633 541 58608 S235 T G P E F V K S V T N E D V T
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001231794 713 76377 S409 T G P D V V K S V T N E D V T
Frog Xenopus laevis NP_001083656 541 59015 S235 T G P D V V K S V T N E D V T
Zebra Danio Brachydanio rerio NP_998090 557 60772 S249 T G P D V V K S V T N E D V T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V9A7 578 62630 A248 A G P P L V K A A T G E E V S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34385 608 66505 A294 G G P P L V K A A T G E E I S
Sea Urchin Strong. purpuratus XP_796906 543 59143 S237 T G P D V V K S V T Q E E V T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LDD8 587 63994 A267 A G P P L V K A A T G E E V S
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 90 99 92.4 N.A. 92.2 91.3 N.A. N.A. 65.3 83.5 80.6 N.A. 34 N.A. 26.9 75.8
Protein Similarity: 100 90.4 99.4 94.7 N.A. 96.4 96.1 N.A. N.A. 71.2 91.3 87.6 N.A. 49.1 N.A. 43.4 84.9
P-Site Identity: 100 0 100 100 N.A. 93.3 86.6 N.A. N.A. 100 100 100 N.A. 46.6 N.A. 40 86.6
P-Site Similarity: 100 13.3 100 100 N.A. 100 93.3 N.A. N.A. 100 100 100 N.A. 73.3 N.A. 73.3 93.3
Percent
Protein Identity: N.A. N.A. N.A. 28.2 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 47.1 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 46.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 73.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 0 0 0 0 0 8 31 24 8 0 0 0 0 0 % A
% Cys: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 54 0 0 0 0 0 0 0 0 62 0 0 % D
% Glu: 0 0 0 16 0 0 0 0 0 0 0 93 31 0 0 % E
% Phe: 0 0 0 0 8 0 0 0 8 0 0 0 0 0 0 % F
% Gly: 8 93 0 0 0 0 0 0 0 0 24 0 0 8 0 % G
% His: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 8 0 0 8 0 % I
% Lys: 0 0 0 0 0 0 93 0 0 0 0 0 0 0 8 % K
% Leu: 8 8 0 0 24 0 0 0 0 0 0 8 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 62 0 8 0 0 % N
% Pro: 0 0 93 24 0 8 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 8 0 0 70 0 0 0 0 0 0 24 % S
% Thr: 70 0 0 0 0 0 0 0 0 93 0 0 0 0 70 % T
% Val: 0 0 0 0 62 93 0 0 70 0 0 0 0 85 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _