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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ALPP
All Species:
4.55
Human Site:
S445
Identified Species:
8.33
UniProt:
P05187
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P05187
NP_001623.3
535
57954
S445
S
P
E
Y
R
Q
Q
S
A
V
P
L
D
E
E
Chimpanzee
Pan troglodytes
XP_001146156
534
57545
S444
S
P
E
Y
R
Q
Q
S
A
V
P
L
D
E
E
Rhesus Macaque
Macaca mulatta
XP_001109717
652
71041
Q572
A
H
N
N
Y
Q
A
Q
S
A
V
P
L
R
H
Dog
Lupus familis
XP_534605
554
59751
A445
D
P
A
Y
K
P
Q
A
A
V
P
L
D
S
E
Cat
Felis silvestris
Mouse
Mus musculus
P24823
529
57193
A441
N
P
T
Y
Q
Q
Q
A
C
V
P
L
S
S
E
Rat
Rattus norvegicus
P15693
540
58384
A443
D
V
N
Y
K
Q
Q
A
A
V
P
L
S
S
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q92058
519
56742
A438
S
A
V
D
F
A
H
A
N
Y
Q
A
Q
A
A
Frog
Xenopus laevis
NP_001091135
530
58155
A444
D
V
N
Y
M
Q
Q
A
A
V
P
L
D
S
E
Zebra Danio
Brachydanio rerio
NP_001020359
521
56944
A442
R
D
D
Y
L
Q
Q
A
A
V
P
L
D
S
E
Tiger Blowfish
Takifugu rubipres
NP_001027823
527
57490
Q447
Q
E
N
N
Y
Q
A
Q
A
A
V
P
L
S
M
Fruit Fly
Dros. melanogaster
Q24238
596
65244
F481
M
W
M
P
L
K
H
F
T
A
E
E
R
A
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001130844
524
57641
Q444
A
H
N
N
Y
Q
A
Q
S
A
V
P
L
R
H
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P11491
566
62986
E437
F
I
K
H
E
I
L
E
K
D
L
G
I
Y
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.5
46.4
71.1
N.A.
73.8
72.4
N.A.
N.A.
55.5
60
55.7
53.4
40.2
N.A.
N.A.
N.A.
Protein Similarity:
100
96
58.9
79.2
N.A.
83.3
82.5
N.A.
N.A.
69.9
74
71
68.6
54.1
N.A.
N.A.
N.A.
P-Site Identity:
100
100
6.6
60
N.A.
53.3
53.3
N.A.
N.A.
6.6
60
60
13.3
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
20
73.3
N.A.
73.3
66.6
N.A.
N.A.
13.3
66.6
73.3
13.3
6.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
56.2
N.A.
N.A.
25
N.A.
Protein Similarity:
N.A.
71.7
N.A.
N.A.
42.2
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
20
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
8
8
0
0
8
24
47
54
31
0
8
0
16
16
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% C
% Asp:
24
8
8
8
0
0
0
0
0
8
0
0
39
0
8
% D
% Glu:
0
8
16
0
8
0
0
8
0
0
8
8
0
16
54
% E
% Phe:
8
0
0
0
8
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% G
% His:
0
16
0
8
0
0
16
0
0
0
0
0
0
0
16
% H
% Ile:
0
8
0
0
0
8
0
0
0
0
0
0
8
0
0
% I
% Lys:
0
0
8
0
16
8
0
0
8
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
16
0
8
0
0
0
8
54
24
0
0
% L
% Met:
8
0
8
0
8
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
8
0
39
24
0
0
0
0
8
0
0
0
0
0
0
% N
% Pro:
0
31
0
8
0
8
0
0
0
0
54
24
0
0
0
% P
% Gln:
8
0
0
0
8
70
54
24
0
0
8
0
8
0
0
% Q
% Arg:
8
0
0
0
16
0
0
0
0
0
0
0
8
16
0
% R
% Ser:
24
0
0
0
0
0
0
16
16
0
0
0
16
47
0
% S
% Thr:
0
0
8
0
0
0
0
0
8
0
0
0
0
0
0
% T
% Val:
0
16
8
0
0
0
0
0
0
54
24
0
0
0
0
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
54
24
0
0
0
0
8
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _