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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IL6
All Species:
12.73
Human Site:
S65
Identified Species:
40
UniProt:
P05231
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P05231
NP_000591.1
212
23718
S65
R
Y
I
L
D
G
I
S
A
L
R
K
E
T
C
Chimpanzee
Pan troglodytes
XP_518992
212
23652
S65
R
Y
I
L
D
G
I
S
A
L
R
K
E
T
C
Rhesus Macaque
Macaca mulatta
P51494
212
23710
S65
R
Y
I
L
D
G
I
S
A
L
R
K
E
T
C
Dog
Lupus familis
XP_855592
207
22996
S60
K
Y
I
L
G
K
I
S
A
L
R
K
E
M
C
Cat
Felis silvestris
Mouse
Mus musculus
P08505
211
24365
V63
T
H
V
L
W
E
I
V
E
M
R
K
E
L
C
Rat
Rattus norvegicus
P20607
211
24339
L63
T
Y
V
L
R
E
I
L
E
M
R
K
E
L
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513877
267
29943
N113
K
T
L
W
K
Q
A
N
G
L
K
D
K
I
C
Chicken
Gallus gallus
Q90YI0
241
26771
V86
R
V
L
R
D
R
A
V
Q
L
Q
D
E
M
C
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
96.2
59.4
N.A.
41
40
N.A.
32.5
33.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
98.5
75.4
N.A.
63.2
64.6
N.A.
52
49.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
73.3
N.A.
40
46.6
N.A.
13.3
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
80
N.A.
60
60
N.A.
46.6
46.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
25
0
50
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
100
% C
% Asp:
0
0
0
0
50
0
0
0
0
0
0
25
0
0
0
% D
% Glu:
0
0
0
0
0
25
0
0
25
0
0
0
88
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
13
38
0
0
13
0
0
0
0
0
0
% G
% His:
0
13
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
50
0
0
0
75
0
0
0
0
0
0
13
0
% I
% Lys:
25
0
0
0
13
13
0
0
0
0
13
75
13
0
0
% K
% Leu:
0
0
25
75
0
0
0
13
0
75
0
0
0
25
0
% L
% Met:
0
0
0
0
0
0
0
0
0
25
0
0
0
25
0
% M
% Asn:
0
0
0
0
0
0
0
13
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
13
0
0
13
0
13
0
0
0
0
% Q
% Arg:
50
0
0
13
13
13
0
0
0
0
75
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
50
0
0
0
0
0
0
0
% S
% Thr:
25
13
0
0
0
0
0
0
0
0
0
0
0
38
0
% T
% Val:
0
13
25
0
0
0
0
25
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
13
13
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
63
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _