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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EDN1
All Species:
4.55
Human Site:
T177
Identified Species:
14.29
UniProt:
P05305
Number Species:
7
Phosphosite Substitution
Charge Score:
-0.86
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P05305
NP_001946.3
212
24425
T177
S
E
E
H
L
R
Q
T
R
S
E
T
M
R
N
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001089874
211
24113
T176
S
E
E
H
L
R
Q
T
R
T
E
T
M
R
N
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P22387
202
22791
R168
L
V
E
G
R
K
L
R
R
L
E
A
I
S
N
Rat
Rattus norvegicus
P22388
202
23116
R168
L
V
E
G
R
K
L
R
R
L
E
A
I
S
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514862
215
24514
R168
L
V
N
R
R
K
M
R
R
M
E
A
I
G
N
Chicken
Gallus gallus
XP_418943
205
22633
K159
F
V
D
S
R
K
M
K
R
L
E
A
V
G
N
Frog
Xenopus laevis
NP_001121271
221
25214
K174
H
H
R
N
K
V
M
K
R
S
E
S
I
K
Q
Zebra Danio
Brachydanio rerio
NP_571594
188
21170
K154
I
R
R
L
R
T
T
K
Q
T
D
V
L
S
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
93.4
N.A.
N.A.
70.2
68.8
N.A.
55.3
41
41.1
34.9
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
N.A.
94.8
N.A.
N.A.
78.3
76.8
N.A.
67.9
57.5
52.4
52.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
N.A.
93.3
N.A.
N.A.
26.6
26.6
N.A.
20
20
20
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
N.A.
100
N.A.
N.A.
40
40
N.A.
33.3
40
46.6
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
50
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
13
0
0
0
0
0
0
0
13
0
0
0
0
% D
% Glu:
0
25
50
0
0
0
0
0
0
0
88
0
0
0
0
% E
% Phe:
13
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
25
0
0
0
0
0
0
0
0
0
25
13
% G
% His:
13
13
0
25
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
13
0
0
0
0
0
0
0
0
0
0
0
50
0
0
% I
% Lys:
0
0
0
0
13
50
0
38
0
0
0
0
0
13
0
% K
% Leu:
38
0
0
13
25
0
25
0
0
38
0
0
13
0
0
% L
% Met:
0
0
0
0
0
0
38
0
0
13
0
0
25
0
0
% M
% Asn:
0
0
13
13
0
0
0
0
0
0
0
0
0
0
75
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
25
0
13
0
0
0
0
0
13
% Q
% Arg:
0
13
25
13
63
25
0
38
88
0
0
0
0
25
0
% R
% Ser:
25
0
0
13
0
0
0
0
0
25
0
13
0
38
0
% S
% Thr:
0
0
0
0
0
13
13
25
0
25
0
25
0
0
0
% T
% Val:
0
50
0
0
0
13
0
0
0
0
0
13
13
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _