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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
INSR
All Species:
13.94
Human Site:
Y539
Identified Species:
34.07
UniProt:
P06213
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P06213
NP_000199.2
1382
156319
Y539
L
F
Y
K
E
A
P
Y
Q
N
V
T
E
F
D
Chimpanzee
Pan troglodytes
Q5IS37
825
92786
R14
P
A
K
C
S
F
W
R
I
F
L
L
G
S
V
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542108
1406
159253
Y564
L
F
Y
K
E
A
P
Y
Q
N
V
T
E
F
D
Cat
Felis silvestris
Mouse
Mus musculus
P15208
1372
155622
Y539
L
F
Y
K
E
A
P
Y
Q
N
V
T
E
F
D
Rat
Rattus norvegicus
P15127
1383
156739
N540
Y
K
E
A
P
Y
Q
N
V
T
E
F
D
G
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P08941
2311
260942
T1220
F
L
L
N
V
Q
S
T
S
E
S
Q
L
F
E
Frog
Xenopus laevis
Q9PVZ4
1362
153727
F549
V
H
Y
K
E
A
P
F
Q
N
V
T
E
F
D
Zebra Danio
Brachydanio rerio
NP_001136144
1353
153245
Y527
V
L
Y
K
E
A
P
Y
K
N
V
T
E
F
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P09208
2144
239757
P847
A
T
I
V
F
K
D
P
R
A
F
I
G
F
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q968Y9
1846
207106
I693
F
F
K
E
V
P
R
I
D
E
N
M
T
I
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
22
N.A.
93.5
N.A.
94.5
94.5
N.A.
N.A.
21.2
70.4
68.5
N.A.
27.6
N.A.
28.2
N.A.
Protein Similarity:
100
36.3
N.A.
95.5
N.A.
96.6
96.9
N.A.
N.A.
35.2
81.7
80.9
N.A.
38.7
N.A.
42.3
N.A.
P-Site Identity:
100
0
N.A.
100
N.A.
100
0
N.A.
N.A.
6.6
80
80
N.A.
6.6
N.A.
6.6
N.A.
P-Site Similarity:
100
6.6
N.A.
100
N.A.
100
6.6
N.A.
N.A.
13.3
93.3
93.3
N.A.
13.3
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
0
10
0
50
0
0
0
10
0
0
0
0
0
% A
% Cys:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
10
0
10
0
0
0
10
0
50
% D
% Glu:
0
0
10
10
50
0
0
0
0
20
10
0
50
0
20
% E
% Phe:
20
40
0
0
10
10
0
10
0
10
10
10
0
70
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
20
10
0
% G
% His:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
0
0
0
0
10
10
0
0
10
0
10
0
% I
% Lys:
0
10
20
50
0
10
0
0
10
0
0
0
0
0
0
% K
% Leu:
30
20
10
0
0
0
0
0
0
0
10
10
10
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% M
% Asn:
0
0
0
10
0
0
0
10
0
50
10
0
0
0
0
% N
% Pro:
10
0
0
0
10
10
50
10
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
10
10
0
40
0
0
10
0
0
10
% Q
% Arg:
0
0
0
0
0
0
10
10
10
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
10
0
10
0
10
0
10
0
0
10
0
% S
% Thr:
0
10
0
0
0
0
0
10
0
10
0
50
10
0
0
% T
% Val:
20
0
0
10
20
0
0
0
10
0
50
0
0
0
20
% V
% Trp:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
50
0
0
10
0
40
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _