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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CCK All Species: 4.55
Human Site: S54 Identified Species: 11.11
UniProt: P06307 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P06307 NP_000720.1 115 12669 S54 S Q R T D G E S R A H L G A L
Chimpanzee Pan troglodytes XP_516386 115 12637 S54 S Q R T D G E S R A H L G A L
Rhesus Macaque Macaca mulatta XP_001107333 104 11690 L44 G A N R N L E L P W L D Q Q G
Dog Lupus familis XP_851915 114 12452 P53 V Q K V D G E P R A H L G A L
Cat Felis silvestris
Mouse Mus musculus P09240 115 12751 P54 V L R T D G E P R A R L G A L
Rat Rattus norvegicus P01355 115 12822 P54 V L R P D S E P R A R L G A L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518765 149 16402 P88 S A S Q R A N P R V L L A R F
Chicken Gallus gallus Q9PU41 130 14072 R69 L D G S F E Q R A T I G A L L
Frog Xenopus laevis P50145 128 14182 R67 Q R T D G D Q R S N I G N A L
Zebra Danio Brachydanio rerio XP_001346140 123 13292 D62 L L T K P E D D E E P R S S L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 23.4 86.9 N.A. 80.8 78.2 N.A. 35.5 50.7 48.4 45.5 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 100 36.5 91.3 N.A. 86.9 82.6 N.A. 49.6 66.9 64.8 58.5 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 6.6 73.3 N.A. 73.3 60 N.A. 20 6.6 13.3 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 13.3 80 N.A. 73.3 60 N.A. 20 20 26.6 20 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 20 0 0 0 10 0 0 10 50 0 0 20 60 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 10 0 10 50 10 10 10 0 0 0 10 0 0 0 % D
% Glu: 0 0 0 0 0 20 60 0 10 10 0 0 0 0 0 % E
% Phe: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 10 % F
% Gly: 10 0 10 0 10 40 0 0 0 0 0 20 50 0 10 % G
% His: 0 0 0 0 0 0 0 0 0 0 30 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 20 0 0 0 0 % I
% Lys: 0 0 10 10 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 20 30 0 0 0 10 0 10 0 0 20 60 0 10 80 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 10 0 10 0 10 0 0 10 0 0 10 0 0 % N
% Pro: 0 0 0 10 10 0 0 40 10 0 10 0 0 0 0 % P
% Gln: 10 30 0 10 0 0 20 0 0 0 0 0 10 10 0 % Q
% Arg: 0 10 40 10 10 0 0 20 60 0 20 10 0 10 0 % R
% Ser: 30 0 10 10 0 10 0 20 10 0 0 0 10 10 0 % S
% Thr: 0 0 20 30 0 0 0 0 0 10 0 0 0 0 0 % T
% Val: 30 0 0 10 0 0 0 0 0 10 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _